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Submit ReviewNS 309
说明： Positive modulator of KCa2 (SK) and KCa3.1 (IK) channels
化学名： 6,7-Dichloro-1H-indole-2,3-dione 3-oxime
纯度： ≥98% (HPLC)
生物活性 for NS 309
NS 309 is a positive modulator of small- and intermediate- conductance Ca2+-activated K+ channels (KCa2 and KCa3.1 channels); increases Ca2+ sensitivity. Displays no activity at BK channels.
技术数据 for NS 309
| 分子量 | 231.04 |
| 公式 | C8H4Cl2N2O2 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 18711-16-5 |
| PubChem ID | 11637204 |
| InChI Key | CVOUSAVHMDXCKG-UHFFFAOYSA-N |
| Smiles | ClC1=C2C(C(C(N2)=O)=NO)=CC=C1Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for NS 309
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 23.1 | 100 |
制备储备液 for NS 309
以下数据基于产品分子量 231.04。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.33 mL | 21.64 mL | 43.28 mL |
| 5 mM | 0.87 mL | 4.33 mL | 8.66 mL |
| 10 mM | 0.43 mL | 2.16 mL | 4.33 mL |
| 50 mM | 0.09 mL | 0.43 mL | 0.87 mL |
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产品说明书 for NS 309
参考文献 for NS 309
参考文献是支持产品生物活性的出版物。
Grgic et al (2009) Endothelial Ca2+-activated K+ channels in normal and impaired EDHF-dilator responses - relevance to cardiovascular pathologies and drug discovery. Br.J.Pharmacol. 157 509 PMID: 19302590
Strobaek et al (2004) Activation of human IK and SK Ca2+-activated K+ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime). Biochim.Biophys.Acta 1665 1 PMID: 15471565
Morimura et al (2006) Voltage-dependent Ca2+-channel block by openers of intermediate and small conductance Ca2+-activated K+ channels in urinary bladder smooth muscle cells. J.Pharm.Sci. 100 237 PMID: 16518073
If you know of a relevant reference for NS 309, please let us know.
关键词: NS 309, NS 309 supplier, NS309, Ca2+-activated, potassium, K+, KCa, channels, activators, positive, modulators, small, intermediate, conductance, SK, IK, KCa2, KCa3, Ca2+-Activated, Potassium, Channels, 3895, Tocris Bioscience
10 篇 NS 309 的引用文献
引用文献是使用了 Tocris 产品的出版物。 NS 309 的部分引用包括：
D'Alessandro et al (2013) KCa3.1 channels are involved in the infiltrative behavior of glioblastoma in vivo. Cell Death Dis 4 e773 PMID: 23949222
Oliveira et al (2010) Altered expression and function of small-conductance (SK) Ca(2+)-activated K+ channels in PilC-treated epileptic rats. Brain Res 1348 187 PMID: 20553876
Wong et al (2014) Sex differences in endothelial function in porcine coronary arteries: a role for H2O2 and gap junctions?. Br J Pharmacol 171 2751 PMID: 24467384
Zhang et al (2015) Molecular overlap in the regulation of SK channels by small molecules and phosphoinositides. Neurochem Int 1 e1500008 PMID: 26366439
Hakim et al (2018) Electrical dynamics of isolated cerebral and skeletal muscle endothelial tubes: Differential roles of G-protein-coupled receptors and K+ channels. Pharmacol Res Perspect 6 e00391 PMID: 29636977
Hipólito et al (2015) In vivo activation of the SK channel in the spinal cord reduces the NMDA receptor antagonist dose needed to produce antinociception in an inflammatory pain model. Pain 156 849 PMID: 25734988
Sarah Y et al (2020) Site-specific opening of the blood-brain barrier by extracellular histones. J Neuroinflammation 17 281 PMID: 32962721
Brant E et al (2021) Brain endothelial cell TRPA1 channels initiate neurovascular coupling. Elife 10 PMID: 33635784
Brant E et al (2021) Endothelial pannexin 1-TRPV4 channel signaling lowers pulmonary arterial pressure in mice. Elife 10 PMID: 34490843
Erik J et al (2021) Methyl-Beta-Cyclodextrin Restores KIR Channel Function in Brain Endothelium of Female Alzheimer's Disease Mice. J Alzheimers Dis Rep 5 693-703 PMID: 34755043
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NS 309 的评论
平均评分: 5 (Based on 1 Review.)
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NS 309 worked nicely on experimental conditions.
By
Anonymous on 10/29/2018
分析类型： In Vitro
种属： Human
NS 309 is a potent Kca channel activator. I worked with 10,20,30,40,50,80,100 micrograms dissolved in DMSO. The product worked nicely in experimental conditions and would suggest to others researching Kca channel activation.
