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NS 6180

Cat. No. 4864 1 次引用 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4864 has been discontinued.

View all Calcium-Activated Potassium (K<sub>Ca</sub>) Channels products.
说明： Potent KCa3.1 (IK) channel blocker
化学名： 4-[[3-(Trifluoromethyl)phenyl]methyl]-2H-1,4-benzothiazin-3(4H)-one
纯度： ≥99% (HPLC)
说明书
引用文献 (1)
评论 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for NS 6180

NS 6180 is a potent KCa3.1 channel blocker (IC50 values are 9, 14 and 15 nM for rat, human and mouse erythrocyte KCa3.1 channels respectively). Exhibits ~ 50% inhibition of KCa1.1, KV1.3, and KV11.1 channels, noradrenaline and dopamine transporters, L-type Ca2+ channels and melatonin receptors at a concentration of 10 μM. Potently inhibits IL-2 and IFN-γ production in rat lymphocytes (IC50 ~ 50 nM); reduces DBNS-induced experimental colitis in rats.

技术数据 for NS 6180

分子量 323.33
公式 C16H12F3NOS
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 353262-04-1
PubChem ID 11837221
InChI Key ZUIJXKLTUFCDGO-UHFFFAOYSA-N
Smiles O=C2N(CC3=CC=CC(C(F)(F)F)=C3)C1=CC=CC=C1SC2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for NS 6180

参考文献是支持产品生物活性的出版物。

Strøbæk et al (2013) NS6180, a new KCa3.1 channel inhibitor prevents T-cell activation and inflammation in a rat model of inflammatory bowel disease. Br.J.Pharmacol. 168 432 PMID: 22891655

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关键词: NS 6180, NS 6180 supplier, NS6180, KCa3.1, potassium, channels, blockers, inhibitors, inhibits, potent, inflammatory, bowel, disease, gardos, channel, KCNN4, anti-inflammatory, Ca2+-Activated, Potassium, Channels, 4864, Tocris Bioscience

1 篇 NS 6180 的引用文献

引用文献是使用了 Tocris 产品的出版物。 NS 6180 的部分引用包括：

Abdulkareem et al (2016) Knockdown of the small conductance Ca(2+) -activated K(+) channels is potently cytotoxic in breast cancer cell lines. Circ Res 173 177 PMID: 26454020

NS 6180 的评论

平均评分: 4 (Based on 1 Review.)

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Great product to study KV channel blocking activity.
By Sadequl Islam on 10/13/2018
分析类型： In Vitro
种属： Mouse

Product is a great K.v channel blocker. Used in studies to understand the mechanism of action of NS 6180 and its differences with other blocker mechanism. The purchased product showed stability and worked well in the study conditions.Would purchase again

Must be dissloved in DMSO

review image