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Submit ReviewNS 9283
说明： Positive allosteric modulator of α4β2 nAChRs
化学名： 3-[3-(3-Pyridinyl)-1,2,4-oxadiazol-5-yl]benzonitrile
纯度： ≥99% (HPLC)
生物活性 for NS 9283
NS 9283 is a positive allosteric modulator of α4β2 receptor; increases the potency of Ach-evoked currents ~60 fold without affecting the maximum efficacy (HEK293-hα4β2 cells). Reduces the rate of recovery from desensitization and slows the rate of deactivation. Displays a synergistic effect on the Emax when given with NS206 at 3α:2β receptors.
化合物库 for NS 9283
NS 9283 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for NS 9283
| 分子量 | 248.24 |
| 公式 | C14H8N4O |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 913830-15-6 |
| PubChem ID | 11998180 |
| InChI Key | HGFXDSQLRSWUBO-UHFFFAOYSA-N |
| Smiles | N#CC1=CC(C2=NC(C3=CN=CC=C3)=NO2)=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for NS 9283
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 12.41 | 50 | |
| 1eq. HCl | 4.96 | 20 |
制备储备液 for NS 9283
以下数据基于产品分子量 248.24。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 8.06 mL | 40.28 mL | 80.57 mL |
| 2.5 mM | 1.61 mL | 8.06 mL | 16.11 mL |
| 5 mM | 0.81 mL | 4.03 mL | 8.06 mL |
| 25 mM | 0.16 mL | 0.81 mL | 1.61 mL |
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产品说明书 for NS 9283
参考文献 for NS 9283
参考文献是支持产品生物活性的出版物。
Grupe et al (2013) Unravelling the mechanism of action of NS9283, a positive allosteric modulator of (α4)3(β2)2 nicotinic ACh receptors. Br.J.Pharmacol. 168 2000 PMID: 23278456
Mohler et al (2014) Discriminative-stimulus effects of NS9283, a nicotinic α4β2* positive allosteric modulator, in nicotine-discriminating rats. Psychopharmacology (Berl). 231 67 PMID: 23925734
Olsen et al (2013) Two distinct allosteric binding sites at α4β2 nicotinic acetylcholine receptors revealed by NS206 and NS9283 give unique insights to binding activity-associated linkage at Cys-loop receptor J.Biol.Chem. 288 35997 PMID: 24169695
If you know of a relevant reference for NS 9283, please let us know.
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关键词: NS 9283, NS 9283 supplier, NS9283, Acetylcholine, nicotinic, ⓮⓶, receptors, positive, allosteric, modulators, PAM, Nicotinic, (a4b2), Receptors, 5112, Tocris Bioscience
1 篇 NS 9283 的引用文献
引用文献是使用了 Tocris 产品的出版物。 NS 9283 的部分引用包括：
Wang et al (2017) Unraveling amino acid residues critical for allosteric potentiation of (α4)3(β2)2-type nicotinic acetylcholine receptor responses. J.Med.Chem. 292 9988 PMID: 28446611
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.
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