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NSC 146109 hydrochloride

Cat. No. 2185 1 次引用 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2185 has been discontinued.

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说明： Cell-permeable, genotype-selective antitumor agent; activates p53-dependent transcription
化学名： (10-Methyl-9-anthracenyl) methyl carbamimidothioic acid ester hydrochloride
纯度： ≥97% (HPLC)
说明书
引用文献 (1)
评论 (1)
文献 (2)
通路 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for NSC 146109 hydrochloride

NSC 146109 hydrochloride is a cell-permeable, genotype-selective antitumor agent that activates p53-dependent transcription. Increases levels of endogenous p53 in tumor cells and protects p53 from Mdm2-mediated degradation. Displays some selectivity for tumor cells vs. normal cells in an MTT cell viability assay.

技术数据 for NSC 146109 hydrochloride

分子量 316.85
公式 C17H16N2S.HCl
储存 Store at -20°C
纯度 ≥97% (HPLC)
CAS Number 59474-01-0
PubChem ID 5458312
InChI Key VIBMUYOXJUCEMA-UHFFFAOYSA-N
Smiles N=C(N)SCC1=C(C=CC=C3)C3=C(C)C2=C1C=CC=C2.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for NSC 146109 hydrochloride

分析证书/产品说明书
化学品安全技术说明书

参考文献 for NSC 146109 hydrochloride

参考文献是支持产品生物活性的出版物。

Dolma et al (2003) Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells. Cancer Cell 3 285 PMID: 12676586

Berkson et al (2005) Pilot screening programme for small molecule activators of p53. Int.J.Cancer 115 701 PMID: 15729694

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关键词: NSC 146109 hydrochloride, NSC 146109 hydrochloride supplier, Cell-permeable, genotype-selective, antitumor, agent, activates, p53-dependent, transcription, p53, Transcription, Factors, MDM2, p14ARF, NSC146109, hydrochloride, 2185, Tocris Bioscience

1 篇 NSC 146109 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 NSC 146109 hydrochloride 的部分引用包括：

Calo et al (2018) Tissue-selective effects of nucleolar stress and rDNA damage in developmental disorders. Nature 554 112 PMID: 29364875

NSC 146109 hydrochloride 的评论

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p53 activation.
By Anonymous on 02/29/2020
分析类型： In Vitro
种属： Human
细胞系/组织： hela

p53-mediated apoptosis after treatment with NSC146109 for 12–16 hours

PMID: 29364875
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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:

  • Cell Cycle and Mitosis
  • DNA Damage Repair
  • Targeted Protein Degradation
  • Ubiquitin Proteasome Pathway
  • Chemotherapy Targets
Cell Cycle & DNA Damage Repair Poster

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

Pathways for NSC 146109 hydrochloride

p53 Signaling Pathway

p53 Signaling Pathway

p53 signaling plays an important role in the co-ordination of the cellular response different types of stress such as DNA damage and hypoxia. The downstream signals lead to apoptosis, senescence and cell cycle arrest.