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NSC 319726

Cat. No. 5065 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5065 has been discontinued.

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说明： Reactivator of mutant p53
化学名： 1-Azetidinecarbothioic acid [1-(2-pyridinyl)ethylidene]hydrazide
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (2)
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生物活性 技术数据 说明书 参考文献

生物活性 for NSC 319726

NSC 319726 is a reactivator of mutant p53. Restores wild type p53 structure and function to the p53R175 mutant. Inhibits growth of fibroblasts expressing the p53R175 mutation (IC50 = 8 nM). Also inhibits growth of xenograft tumors expressing the p53R175 mutation in vivo.

技术数据 for NSC 319726

分子量 234.32
公式 C11H14N4S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 71555-25-4
PubChem ID 5351307
InChI Key XDHBUMNIQRLHGO-UKTHLTGXSA-N
Smiles C/C(C1=NC=CC=C1)=N\NC(N2CCC2)=S

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for NSC 319726

参考文献是支持产品生物活性的出版物。

Yu et al (2012) Allele-specific p53 mutant reactivation. Cancer Cell 21 614 PMID: 22624712

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关键词: NSC 319726, NSC 319726 supplier, NSC319726, mutant, p53, reactivators, activators, p53R175, transcription, factors, cell, cycle, apoptosis, 5065, Tocris Bioscience

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:

  • Cell Cycle and Mitosis
  • DNA Damage Repair
  • Targeted Protein Degradation
  • Ubiquitin Proteasome Pathway
  • Chemotherapy Targets
Cell Cycle & DNA Damage Repair Poster

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

Pathways for NSC 319726

p53 Signaling Pathway

p53 Signaling Pathway

p53 signaling plays an important role in the co-ordination of the cellular response different types of stress such as DNA damage and hypoxia. The downstream signals lead to apoptosis, senescence and cell cycle arrest.