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Submit ReviewNSC 405020
说明： Histone deacetylase inhibitor
化学名： 3,4-Dichloro-N-(1-methylbutyl)benzamide
纯度： ≥99% (HPLC)
生物活性 for NSC 405020
NSC 405020 is a membrane type-1 matrix metalloproteinase (MT1-MMP) inhibitor (IC50 > 100 μmol/L). Directly interacts with the hemopexin domain (PEX) of MT1-MMP, affecting homodimerization and repressing its pro-tumorigenic activity in vivo. Displays no effect on the catalytic activity of MT1-MMP or MMP-2.
化合物库 for NSC 405020
NSC 405020 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。
技术数据 for NSC 405020
| 分子量 | 260.16 |
| 公式 | C12H15Cl2NO |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 7497-07-6 |
| PubChem ID | 346721 |
| InChI Key | ARDYECYBETXQFD-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(C(NC(C)CCC)=O)C=C1Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for NSC 405020
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 26.02 | 100 | |
| ethanol | 26.02 | 100 |
制备储备液 for NSC 405020
以下数据基于产品分子量 260.16。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.84 mL | 19.22 mL | 38.44 mL |
| 5 mM | 0.77 mL | 3.84 mL | 7.69 mL |
| 10 mM | 0.38 mL | 1.92 mL | 3.84 mL |
| 50 mM | 0.08 mL | 0.38 mL | 0.77 mL |
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产品说明书 for NSC 405020
参考文献 for NSC 405020
参考文献是支持产品生物活性的出版物。
Remacle et al (2012) Novel MT1-MMP small-molecule inhibitors based on insights into hemopexin domain function in tumor growth. Cancer Res. 72 2339 PMID: 22406620
If you know of a relevant reference for NSC 405020, please let us know.
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关键词: NSC 405020, NSC 405020 supplier, NSC405020, Membrane, type-1, matrix, metalloproteinase, MT1-MMP, inhibitors, inhibits, hemopexin, domains, PEX, pro-tumorigenic, antitumor, MMP2, MMP-2, MMP, Matrix, Metalloprotease, Class, I, HDACs, 4902, Tocris Bioscience
5 篇 NSC 405020 的引用文献
引用文献是使用了 Tocris 产品的出版物。 NSC 405020 的部分引用包括：
Kumar et al (2018) MMP Secretion Rate and Inter-invadopodia Spacing Collectively Govern Cancer Invasiveness. Biophys J 114 650 PMID: 29414711
Clancy et al (2015) Regulated delivery of molecular cargo to invasive tumour-derived microvesicles. Proc Natl Acad Sci U S A 6 6919 PMID: 25897521
Helena et al (2017) Mesenchymal stem cells differentially affect the invasion of distinct glioblastoma cell lines. Oncotarget 8 25482-25499 PMID: 28424417
Bernard et al (2022) Megakaryocytes form linear podosomes devoid of digestive properties to remodel medullar matrix. Sci Rep 12 6255 PMID: 35428815
Isabelle et al (2020) Basement membrane remodelling regulates mouse embryogenesis. Nature 582 253-258 PMID: 32523119
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.
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In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.
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This poster summarizes the main epigenetic targets in cancer. The dysregulation of epigenetic modifications has been shown to result in oncogenesis and cancer progression. Unlike genetic mutations, epigenetic alterations are considered to be reversible and thus make promising therapeutic targets.
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Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.