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NSC 636819

Cat. No. 5287 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： KDM4A/KDM4B inhibitor
化学名： 1,5-Bis[(1E)-2-(3,4-dichlorophenyl)ethenyl]-2,4-dinitrobenzene
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for NSC 636819

NSC 636819 is a KDM4A/KDM4B inhibitor; inhibits histone demethylase activity on H3K9me3 and induces apoptosis in LNCaP prostate cancer cells in vitro. Also negatively regulates androgen-responsive genes.

技术数据 for NSC 636819

分子量 510.15
公式 C22H12Cl4N2O4
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1618672-71-1
PubChem ID 6288112
InChI Key YYZPXBXVBQSBDG-IJIVKGSJSA-N
Smiles ClC(C=C1)=C(Cl)C=C1/C=C/C2=C([N+]([O-])=O)C=C([N+]([O-])=O)C(/C=C/C3=CC=C(Cl)C(Cl)=C3)=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NSC 636819

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 5.1 10

制备储备液 for NSC 636819

以下数据基于产品分子量 510.15。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.1 mM 19.6 mL 98.01 mL 196.02 mL
0.5 mM 3.92 mL 19.6 mL 39.2 mL
1 mM 1.96 mL 9.8 mL 19.6 mL
5 mM 0.39 mL 1.96 mL 3.92 mL

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参考文献 for NSC 636819

参考文献是支持产品生物活性的出版物。

Chu et al (2014) KDM4B as a target for prostate cancer: structural analysis and selective inhibition by a novel inhibitor. J.Med.Chem. 57 5975 PMID: 24971742

If you know of a relevant reference for NSC 636819, please let us know.

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关键词: NSC 636819, NSC 636819 supplier, NSC636819, KDM4A, KDM4B, inhibitors, inhibits, prostate, cancer, androgen-responsive, histones, demethylases, Histone, Demethylases, 5287, Tocris Bioscience

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