NVP BHG 712

Name: NVP BHG 712
Brand: Tocris Bioscience
SKU: 4405

Cat. No. 4405 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4405 has been discontinued.

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说明： Potent EphB4 kinase inhibitor

化学名： 4-Methyl-3-[[1-methyl-6-(3-pyridinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino]-N-[3-(trifluoromethyl)phenyl]benzamide trifluoroacetate

纯度： ≥98% (HPLC)

说明书

引用文献 (1)

文献 (1)

生物活性技术数据说明书参考文献

生物活性 for NVP BHG 712

Selective inhibitor of EphB4 kinase; exhibits selectivity for EphB4 over more than 40 other kinases in vitro, including FGFR3. Inhibits EphB4 autophosphorylation in transiently transfected HEK 293 cells. Also inhibits VEGF-induced angiogenesis in vivo; thought to inhibit EphB4 forward signaling. Orally active.

技术数据 for NVP BHG 712

分子量	617.5
公式	C₂₆H₂₀F₃N₇O.CF₃CO₂H
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	940310-85-0
PubChem ID	73332408
InChI Key	KCYJGZKWKFCVGC-UHFFFAOYSA-N
Smiles	CN1N=CC2=C1N=C(C4=CC=CN=C4)N=C2NC3=CC(C(NC5=CC=CC(C(F)(F)F)=C5)=O)=CC=C3C.OC(C(F)(F)F)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for NVP BHG 712

分析证书/产品说明书

化学品安全技术说明书

参考文献 for NVP BHG 712

参考文献是支持产品生物活性的出版物。

Martiny-Baron et al (2010) The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesis. Angiogenesis. 13 259 PMID: 20803239

Wnuk et al (2012) Podocyte EphB4 signaling helps recovery from glomerular injury. Kidney Int. 81 1212 PMID: 22398409

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关键词: NVP BHG 712, NVP BHG 712 supplier, NVPBHG712, EphB4, kinase, inhibitors, inhibits, ephrinB2, EphB2, ephrin, VEGF, angiogenesis, antiangiogenics, ephrins, Eph, Receptors, 4405, Tocris Bioscience

1 篇 NVP BHG 712 的引用文献

引用文献是使用了 Tocris 产品的出版物。 NVP BHG 712 的部分引用包括：

Krupke et al (2016) Eph and Ephrin function in dispersal and epithelial insertion of pigmented immunocytes in sea urchin embryos. Elife 5 PMID: 27474796

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