N^ω-Propyl-L-arginine hydrochloride

Name: N ω -Propyl-L-arginine hydrochloride
Brand: Tocris Bioscience
SKU: 1200

Cat. No. 1200 4 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

This product has been withdrawn from sale and is superseded by ARL 17477 dihydrochloride (Cat. No. 3319)

说明： Highly selective inhibitor of nNOS

化学名： N⁵-[Imino(propylamino)methyl]-L-ornithine hydrochloride

纯度： ≥98% (HPLC)

说明书

引用文献 (4)

生物活性技术数据说明书参考文献

生物活性 for N^ω-Propyl-L-arginine hydrochloride

N^ω-Propyl-L-arginine hydrochloride is a highly selective and potent inhibitor of nNOS (K_i = 57 nM). Displays 3158-fold and 149-fold selectivity over iNOS and eNOS respectively. Hypotensive in vivo.

技术数据 for N^ω-Propyl-L-arginine hydrochloride

分子量	252.74
公式	C₉H₂₀N₄O₂.HCl
储存	Desiccate at RT
纯度	≥98% (HPLC)
CAS Number	2321366-46-3
PubChem ID	447180
InChI Key	AOMXURITGZJPKB-ZETCQYMHSA-N
Smiles	N=C(NCCC[C@H](N)C(O)=O)NCCC.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for N^ω-Propyl-L-arginine hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for N^ω-Propyl-L-arginine hydrochloride

参考文献是支持产品生物活性的出版物。

Kakoki et al (2001) The influence of nitric oxide synthase 1 on blood flow and interstitial nitric oxide in the kidney. Am.J.Physiol.Regul.Integr.Comp.Physiol. 281 R91 PMID: 11404282

Zhang et al (1997) Potent and selective inhibition of neuronal nitric oxide synthase by N^ω-propyl-L-arginine. J.Med.Chem. 40 3869 PMID: 9397167

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关键词: Nw-Propyl-L-arginine hydrochloride, Nw-Propyl-L-arginine hydrochloride supplier, selective, inhibitors, inhibits, nNOS, Nitric, Oxide, Signaling, Signalling, Neuronal, NO, Synthases, Nomega-Propyl-L-arginine, hydrochloride, 137361-05-8, 1200, Tocris Bioscience

4 篇 N^ω-Propyl-L-arginine hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 N^ω-Propyl-L-arginine hydrochloride 的部分引用包括：

Xu et al (2016) Cultured networks of excitatory projection neurons and inhibitory interneurons for studying human cortical neurotoxicity. Sci Transl Med 8 333ra48 PMID: 27053772

Lu et al (2015) Neuronal and Endothelial Nitric Oxide Synthases in the Paraventricular Nucleus Modulate Sympathetic Overdrive in Ins-Resistant Rats. Diabetes 10 e0140762 PMID: 26485682

Slesinger (2001) Ion selectivity filter regulates local anesthetic inhibition of G-protein-gated inwardly rectifying K+ channels. Biophys J 80 707 PMID: 11159438

Mathison et al (2004) Effects of cannabinoid receptor-2 activation on accelerated gastrointestinal transit in lipopolysaccharide-treated rats. Br J Pharmacol 142 1247 PMID: 15249429