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说明： Silent antagonist for putative abnormal-CBD (Cat. No. 1297) receptor
化学名： 1,3-Dimethoxy-5-methyl-2-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]benzene
纯度： ≥97% (HPLC)
生物活性 for O-1918
O-1918 is a selective, silent antagonist of a putative endothelial anandamide receptor distinct from CB1 or CB2 receptors. Inhibits vasodilation and cell migration induced by abnormal-cannabidiol (abn-CBD; Cat. No. 1297).
许可信息
Sold under license from the NIH, US patent 60/312,674
技术数据 for O-1918
| 分子量 | 286.41 |
| 公式 | C19H26O2 |
| 储存 | Store at -20°C |
| 纯度 | ≥97% (HPLC) |
| CAS Number | 536697-79-7 |
| PubChem ID | 40469923 |
| InChI Key | ICHJMVMWPKLUKT-JKSUJKDBSA-N |
| Smiles | COC1=CC(C)=CC(OC)=C1[C@@H]1C=C(C)CC[C@H]1C(C)=C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for O-1918
参考文献 for O-1918
参考文献是支持产品生物活性的出版物。
Offertáler et al (2003) Selective ligands and cellular effectors of a G protein-coupled endothelial cannabinoid receptor. Mol.Pharmacol. 63 699 PMID: 12606780
Mo et al (2004) Atypical cannabinoid stimulates endothelial cell migration via a Gi/Go coupled receptor distinct from CB1, CB2 or EDG-1. Eur.J.Pharmacol. 489 21 PMID: 15063151
Hoi and Hiley (2006) Vasorelaxant effects of oleamide in rat small mesenteric artery indicate action at a novel cannabinoid receptor. Br.J.Pharmacol. 147 560 PMID: 16415907
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关键词: O-1918, O-1918 supplier, Silent, antagonists, putative, abnormal-CBD, receptor, cannabinoids, Receptors, 0-1918, Other, Cannabinoids, 2288, Tocris Bioscience
3 篇 O-1918 的引用文献
引用文献是使用了 Tocris 产品的出版物。 O-1918 的部分引用包括：
Schwartz et al (2018) Up-regulation of heme oxygenase-1 expression and inhibition of disease-associated features by cannabidiol in vascular smooth muscle cells. Oncotarget 9 34595 PMID: 30349652
Krohn et al (2016) Abnormal cannabidiol attenuates experimental colitis in mice, promotes wound healing and inhibits neutrophil recruitment. J Inflamm (Lond) 13 21 PMID: 27418880
Herradón et al (2007) Characterization of the vasorelaxant mechanisms of the endocannabinoid anandamide in rat aorta. Br J Pharmacol 152 699 PMID: 17704831
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Cannabinoid Receptor Ligands Scientific Review
Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.