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Submit ReviewAbn-CBD
Description: Selective GPR55 agonist; neurobehaviorally inactive
Alternative Names: Abnormal-cannabidiol
Chemical Name: 4-[(1R,6R)-3-Methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol
Purity: ≥97% (HPLC)
Biological Activity for Abn-CBD
Abn-CBD is a neurobehaviorally inactive cannabinoid that acts as a selective agonist for GPR55 (EC50 values are 2.5, >30 and >30 μM at GPR55, CB1 and CB2 receptors respectively). Increases phosphorylation of protein kinases in, and migration of, human umbilical vein endothelial cells.
Technical Data for Abn-CBD
| M. Wt | 314.47 |
| Formula | C21H30O2 |
| Storage | Desiccate at -20°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 22972-55-0 |
| PubChem ID | 89949 |
| InChI Key | YWEZXUNAYVCODW-RBUKOAKNSA-N |
| Smiles | C=[C@](C)[C@@H]1CCC(C)=C[C@H]1[C@]2=C(O)C=C(O)C=C2CCCCC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Abn-CBD
References for Abn-CBD
References are publications that support the biological activity of the product.
Ho and Hiley (2003) Vasodilator actions of abnormal-cannabidiol in rat isolated small mesenteric artery. Br.J.Pharmacol. 138 1320 PMID: 12711633
Jarai et al (1999) Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors. Proc.Natl.Acad.Sci.U.S.A. 96 14136 PMID: 10570211
Mo et al (2004) Atypical cannabinoid stimulates endothelial cell migration via a Gi/Go-coupled receptor distinct from CB1, CB2 or EDG-1. Eur.J.Pharmacol. 489 21 PMID: 15063151
Ryberg et al (2007) The orphan receptor GPR55 is a novel cannabinoid receptor. Br.J.Pharmacol. 152 1092 PMID: 17876302
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Keywords: Abn-CBD, Abn-CBD supplier, Selective, GPR55, agonists, neurobehaviorally, inactive, cannabinoids, receptors, cannabidiol, Abnormal-cannabidiol, 1297, Tocris Bioscience
3 Citations for Abn-CBD
Citations are publications that use Tocris products. Selected citations for Abn-CBD include:
Hao et al (2015) Cannabidiol Protects against Doxorubicin-Induced Cardiomyopathy by Modulating Mitochondrial Function and Biogenesis. Cell Death Dis 21 38 PMID: 25569804
Esposito et al (2007) Cannabidiol in vivo blunts beta-amyloid induced neuroinflammation by suppressing IL-1beta and iNOS expression. Br J Pharmacol 151 1272 PMID: 17592514
Yang et al (2014) Cannabidiol protects liver from binge alcohol-induced steatosis by mechanisms including inhibition of oxidative stress and increase in autophagy. Free Radic Biol Med 68 260 PMID: 24398069
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Cannabinoid Receptor Ligands Scientific Review
Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.