O8 OGG1 Inhibitor

Cat. No. 6236 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor

化学名： 3,4-Dichlorobenzo[b]thiophene-2-carbohydrazide

纯度： ≥98% (HPLC)

引用文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for O8 OGG1 Inhibitor

O8 OGG1 Inhibitor is a potent and selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor (IC₅₀ = 0.2 μM in a gel based assay). Exhibits > 200-fold selectivity for OGG1 over other DNA glycosylases, NEIL1 and NTH1.

化合物库 for O8 OGG1 Inhibitor

O8 OGG1 Inhibitor is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for O8 OGG1 Inhibitor

分子量	261.13
公式	C₉H₆Cl₂N₂OS
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	350997-39-6
PubChem ID	874733
InChI Key	HSSHUDKWJRJKPV-UHFFFAOYSA-N
Smiles	NNC(=O)C1=C(Cl)C2=C(Cl)C=CC=C2S1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for O8 OGG1 Inhibitor

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	26.11	100

制备储备液 for O8 OGG1 Inhibitor

以下数据基于产品分子量 261.13。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.83 mL	19.15 mL	38.3 mL
5 mM	0.77 mL	3.83 mL	7.66 mL
10 mM	0.38 mL	1.91 mL	3.83 mL
50 mM	0.08 mL	0.38 mL	0.77 mL

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产品说明书 for O8 OGG1 Inhibitor

分析证书/产品说明书

化学品安全技术说明书

参考文献 for O8 OGG1 Inhibitor

参考文献是支持产品生物活性的出版物。

Donley et al (2015) Small molecule inhibitors of 8-oxoguanine DNA glycosylase-1 (OGG1). ACS Chem.Biol. 10 2334 PMID: 26218629

If you know of a relevant reference for O8 OGG1 Inhibitor, please let us know.

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关键词: O8 OGG1 Inhibitor, O8 OGG1 Inhibitor supplier, O8OGG1, Inhibitor, inhibitors, inhibits, potent, selective, 8-Oxoguanine, DNA, Glycosylase-1, OGG1, base, excision, repair, pathway, BER, Glycosylases, 6236, Tocris Bioscience

1 篇 O8 OGG1 Inhibitor 的引用文献

引用文献是使用了 Tocris 产品的出版物。 O8 OGG1 Inhibitor 的部分引用包括：

Gustavo F et al (2021) Ginkgolic Acid Inhibits Coronavirus Strain 229E Infection of Human Epithelial Lung Cells. Pharmaceuticals (Basel) 14 PMID: 34681204

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