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OB-1

Cat. No. 6545 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Stomatin-like protein-3 (STOML3) oligomerization inhibitor
化学名： Ethyl 5-(1-methyl-4-nitro-1H-imidazol-5-yloxy)-2-phenylbenzofuran-3-carboxylate
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for OB-1

OB-1 is a stomatin-like protein-3 (STOML3) oligomerization inhibitor. Reduces STOML3 cluster size in the plasma membrane. Decreases mechanically-induced Piezo1 but not ASIC3 current amplitudes in N2a cells and cultured mouse sensory neurons in vitro. Subcutaneous administration in mice reversibly silences touch receptor activity and inhibits paw withdrawal reflex in a mouse neuropathic pain model.

化合物库 for OB-1

OB-1 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for OB-1

分子量 407.38
公式 C21H17N3O6
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 300803-69-4
PubChem ID 1113704
InChI Key UJHGRDVYTTVJFD-UHFFFAOYSA-N
Smiles CCOC(C1=C(C2=CC=CC=C2)OC3=CC=C(C=C13)OC4=C([N+]([O-])=O)N=CN4C)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for OB-1

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 20.37 50

制备储备液 for OB-1

以下数据基于产品分子量 407.38。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 4.91 mL 24.55 mL 49.09 mL
2.5 mM 0.98 mL 4.91 mL 9.82 mL
5 mM 0.49 mL 2.45 mL 4.91 mL
25 mM 0.1 mL 0.49 mL 0.98 mL

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参考文献 for OB-1

参考文献是支持产品生物活性的出版物。

Wetzel et al (2017) Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity. Nat.Neurosci. 20 209 PMID: 27941788

If you know of a relevant reference for OB-1, please let us know.

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关键词: OB-1, OB-1 supplier, OB1, Stomatin-like, protein-3, oligomerization, inhibitors, inhibits, mechanosensitive, allodynia, neuropathic, pain, Piezo1, STOML3, Piezo, Channels, 6545, Tocris Bioscience

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