OB 24 hydrochloride

Cat. No. 6119 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Potent and selective heme oxygenase 1 (HO-1) inhibitor

化学名： 1-[[2-[2-(4-Bromophenyl)ethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazole hydrochloride

纯度： ≥98% (HPLC)

引用文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for OB 24 hydrochloride

OB 24 hydrochloride is a potent and selective heme oxygenase 1 (HO-1) inhibitor (IC₅₀ values are 1.9 and >100 μM for HO-1 and HO-2 respectively), reduces protein carbonylation and reactive oxygen species formation in advanced prostate cancer cells (PCA). Inhibits cell proliferation in vitro and PCA tumor growth and lymph node/lung metastases in vivo. Synergizes with Taxol (Cat. No. 1097).

化合物库 for OB 24 hydrochloride

OB 24 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for OB 24 hydrochloride

分子量	373.67
公式	C₁₅H₁₇BrN₂O₂.HCl
储存	Desiccate at RT
纯度	≥98% (HPLC)
CAS Number	939825-12-4
PubChem ID	45265865
InChI Key	YSOWYXRHOAXXTG-UHFFFAOYSA-N
Smiles	BrC1=CC=C(C=C1)CCC2(OCCO2)CN3C=CN=C3.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for OB 24 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	37.4	100
	DMSO	37.37	100

制备储备液 for OB 24 hydrochloride

以下数据基于产品分子量 373.67。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.68 mL	13.38 mL	26.76 mL
5 mM	0.54 mL	2.68 mL	5.35 mL
10 mM	0.27 mL	1.34 mL	2.68 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

产品说明书 for OB 24 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for OB 24 hydrochloride

参考文献是支持产品生物活性的出版物。

Alaoui-Jamali et al (2009) A novel experimental heme oxygenase-1-targeted therapy for hormone-refractory prostate cancer. Cancer Res. 69 8017 PMID: 19808972

If you know of a relevant reference for OB 24 hydrochloride, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Heme Oxygenase Inhibitors

关键词: OB 24 hydrochloride, OB 24 hydrochloride supplier, OB24, HCl, selective, heme, oxygenase, 1, inhibitors, inhibits, Taxol, potent, HO1, HO_1, Heme, Oxygenase, 6119, Tocris Bioscience

2 篇 OB 24 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 OB 24 hydrochloride 的部分引用包括：

Carolyn J et al (2021) Oxidized Lipoproteins Promote Resistance to Cancer Immunotherapy Independent of Patient Obesity. Cancer Immunol Res 9 214-226 PMID: 33303575

Thomas P et al (2021) Fructose Promotes Cytoprotection in Melanoma Tumors and Resistance to Immunotherapy. Cancer Immunol Res 9 227-238 PMID: 33023966

您是否知道使用了 Tocris OB 24 hydrochloride 的优秀论文？请告知我们.