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Submit ReviewOctreotide
说明： sst2, sst3 and sst5 agonist
别名： SMS 201995,Sandostatin
纯度： ≥95% (HPLC)
生物活性 for Octreotide
Octreotide is a peptide agonist for sst2, sst3 and sst5 somatostatin receptors. IC50/Kd values (nM) at cloned human somatostatin receptors are: 290 - 1140 (sst1), 0.4 - 2.1 (sst2), 4.4 - 34.5 (sst3), > 1000 (sst4), and 5.6 - 32 (sst5).
技术数据 for Octreotide
| 分子量 | 1019.24 |
| 公式 | C49H66N10O10S2 |
| 序列 |
FCFWKTCT (Modifications: Phe-1 = D-Phe, Trp-4 = D-Trp, Thr-8 = Thr-ol, Disulfide bridge between 2-7) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 83150-76-9 |
| PubChem ID | 90488715 |
| InChI Key | DEQANNDTNATYII-XOEBDJBESA-N |
| Smiles | [H]N[C@@H](CC1=CC=CC=C1)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=CC=C2)NC1=O)[C@@H](C)O)C(=O)N[C@H](CO)[C@@H](C)O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Octreotide
| 溶解性 | Soluble to 1.20 mg/ml in water |
产品说明书 for Octreotide
参考文献 for Octreotide
参考文献是支持产品生物活性的出版物。
Hoyer et al (1994) Molecular pharmacology of somatostatin receptors. Naunyn Schmiedebergs Arch.Pharmacol. 350 441 PMID: 7870182
Raynor et al (1993) Cloned somatostatin receptors: identification of subtype-selective peptides and demonstration of high affinity binding to linear peptides. Mol.Pharmacol. 43 838 PMID: 8100350
Hannon et al (2002) Drug design at peptide receptors. Somatostatin receptor ligands. J.Mol.Neurosci. 18 15
If you know of a relevant reference for Octreotide, please let us know.
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关键词: Octreotide, Octreotide supplier, sst2, sst3, sst5, agonists, Receptors, Somatostatin, SMS201995, SMS, 201995, Sandostatin, 1818, Tocris Bioscience
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Octreotide 的评论
平均评分: 5 (Based on 1 Review.)
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Octreotide activates cAMP.
By
Kishor Pant on 04/07/2022
分析类型： In Vitro
种属： Human
细胞系/组织： HepG2, Huh, HuCCT1
It can activate cAMP in the cell via activating somatostatin receptors.
Please mind that it can induce cell growth at low dose and can inhibit the cell growth at higher concentrations.
