OD 36 hydrochloride

Name: OD 36 hydrochloride
Brand: Tocris Bioscience
SKU: 6598

Cat. No. 6598 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6598 has been discontinued.

View all Receptor Interacting Protein Kinases products.

说明： Potent RIP2 kinase inhibitor

化学名： 6-Chloro-10,11,14,17-tetrahydro-13H-1,16-etheno-4,8-metheno-1H-pyrazolo[3,4-g][1,14,4,6]dioxadiazacyclohexadecine hydrochloride

纯度： ≥98% (HPLC)

说明书

引用文献

生物活性技术数据说明书参考文献

生物活性 for OD 36 hydrochloride

OD 36 hydrochloride is a potent receptor-interacting protein kinase 2 (RIPK2) inhibitor (IC₅₀ = 5.3 nM). Displays similar % inhibition against ALK-2 and SIK2 at 100 nM. Downregulates expression of a panel of RIPK2-dependent genes. Inhibits recruitment of inflammatory cells in a mouse MDP-induced peritonitis model.

化合物库 for OD 36 hydrochloride

OD 36 hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for OD 36 hydrochloride

分子量	367.23
公式	C₁₆H₁₅ClN₄O₂.HCl
储存	Desiccate at RT
纯度	≥98% (HPLC)
CAS Number	1638644-62-8
Smiles	ClC1=CC(C2=C3N=C(NCCOCCO4)C=CN3N=C2)=CC4=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for OD 36 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for OD 36 hydrochloride

参考文献是支持产品生物活性的出版物。

Tigno-Aranjuez et al (2014) In vivo inhibition of RIPK2 kinase alleviates inflammatory disease. J.Biol.Chem. 289 29651 PMID: 25213858

Sánchez-Duffhues et al (2019) Development of macrocycle kinase inhibitors for ALK2 using Fibrodysplasia ossificans progressiva-derived endothelial cells. JBMRPlus 3 e10230 PMID: 31768489

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篇 OD 36 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 OD 36 hydrochloride 的引用文献。