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Submit ReviewOG-L002
说明： Potent LSD1 inhibitor
化学名： 4'-((1R,2S)-2-aminocyclopropyl)biphenyl-3-ol
纯度： ≥98% (HPLC)
生物活性 for OG-L002
OG-L002 is a potent LSD1 inhibitor (IC50 = 20 nM). Exhibits some selectivity for LSD1 over MAO-B and MAO-A (IC50 values are 0.72 and 1.38 μM, respectively). Inhibits herpes simplex virus (HSV) immediate early gene expression and viral yield in vitro. Suppresses HSV primary infection in vivo.
技术数据 for OG-L002
| 分子量 | 225.29 |
| 公式 | C15H15NO |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1357302-64-7 |
| PubChem ID | 56639570 |
| InChI Key | DSOJSZXQRJGBCW-CABCVRRESA-N |
| Smiles | N[C@H]1C[C@@H]1C2=CC=C(C3=CC(O)=CC=C3)C=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for OG-L002
参考文献 for OG-L002
参考文献是支持产品生物活性的出版物。
Liang et al (2013) A novel selective LSD1/KDM1A inhibitor epigenetically blocks herpes simplex virus lytic replication and reactivation from latency. MBio. 4 e00558 PMID: 23386436
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关键词: OG-L002, OG-L002 supplier, Antiviral, LSD1, inhibitors, inhibits, lysine, demethylase, 1, inhibitor, herpes, simplex, virus, HSV, potent, Histone, Demethylases, Herpes, Simplex, Viruses, 6244, Tocris Bioscience
1 篇 OG-L002 的引用文献
引用文献是使用了 Tocris 产品的出版物。 OG-L002 的部分引用包括：
Chris et al (2020) Neuronal hyperexcitability is a DLK-dependent trigger of herpes simplex virus reactivation that can be induced by IL-1. Elife 9 PMID: 33350386
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.