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Oleanolic acid

Cat. No. 6026 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective GPBA receptor (TGR5) partial agonist
化学名： (3β)-3-Hydroxyolean-12-en-28-oic acid
纯度： ≥97% (HPLC)
说明书
引用文献
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通路 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for Oleanolic acid

Oleanolic acid is a GPBA receptor (TGR5) partial agonist (EC50 = 2.25 μM; 72% efficacy). Displays no activity at FXR. Also inhibits protein phosphate 1B (PTP1B) and glycogen phosphorylase. Suppresses cell proliferation and increases apoptosis in T24 bladder cancer cells. Antidiabetic, antihyperglycaemic, antitumor and hepatoprotective.

技术数据 for Oleanolic acid

分子量 456.7
公式 C30H48O3
储存 Store at +4°C
纯度 ≥97% (HPLC)
CAS Number 508-02-1
PubChem ID 10494
InChI Key MIJYXULNPSFWEK-GTOFXWBISA-N
Smiles [H][C@@]12CC(C)(CC[C@]1(C(O)=O)CC[C@@]3(C2=CC[C@@]4([C@]5(CC[C@@H](C(C)([C@@]5(CC[C@@]34C)[H])C)O)C)[H])C)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Oleanolic acid

参考文献是支持产品生物活性的出版物。

Genet et al (2010) Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: potential impact in diabetes. J.Med.Chem. 53 178 PMID: 19911773

Mu et al (2015) Oleanolic acid suppresses the proliferation of human bladder cancer by Akt/mTOR/S6K and ERK1/2 signaling. Int.J.Clin.Exp.Pathol. 8 13864 PMID: 26823699

Castellano et al (2013) Biochemical basis of the antidiabetic activity of oleanolic acid and related pentacyclic triterpenes. Diabetes 62 1791 PMID: 23704520

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Pathways for Oleanolic acid

Insulin Signaling Pathway

Insulin Signaling Pathway

Signaling through the insulin pathway is fundamental for the regulation of intracellular glucose levels. This pathway can become dysregulated in diabetes.