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Olmesartan

Cat. No. 4616 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4616 has been discontinued.

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说明： Potent AT1 antagonist
化学名： 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid
纯度： ≥99% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 说明书 参考文献

生物活性 for Olmesartan

Olmesartan is a potent angiotensin II type I (AT1) receptor antagonist (IC50 = 6.7 nM at hAT1 receptors). Improves cognitive function in a mouse model of hypertension- and hyperlipidemia-associated cognitive decline; ameliorates arterial stiffness in a rat model of chronic renal failure.

化合物库 for Olmesartan

Olmesartan is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Olmesartan

分子量 446.5
公式 C24H26N6O3
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 144689-24-7
PubChem ID 158781
InChI Key VTRAEEWXHOVJFV-UHFFFAOYSA-N
Smiles CCCC1=NC(C(C)(C)O)=C(C(O)=O)N1CC2=CC=C(C3=CC=CC=C3C4=NN=NN4)C=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Olmesartan

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Olmesartan

参考文献是支持产品生物活性的出版物。

Mogi et al (2007) Inhibition of cognitive decline in mice fed a high-salt and cholesterol diet by the angiotensin receptor blocker, olmes. Neuropharmacology 53 899 PMID: 18028965

Chuang et al (2012) Effects of olmes. on arterial stiffness in rats with chronic renal failure. Cardiovasc.Diabetol. 11 66 PMID: 22694778

Ojima et al (2011) In vitro antagonistic properties of a new angiotensin type 1 receptor blocker, azilsartan, in receptor binding and function studies. J.Pharmacol.Exp.Ther. 336 801 PMID: 21123673

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关键词: Olmesartan, Olmesartan supplier, rnh, 6270, rnh6270, olmetec, benicar, potent, antagonists, angiotensin, II, receptors, blockers, ARBs, AT1, antihypertensive, Angiotensin, Receptors, 4616, Tocris Bioscience

2 篇 Olmesartan 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Olmesartan 的部分引用包括：

Robert J et al (2019) Distinctive Activation Mechanism for Angiotensin Receptor Revealed by a Synthetic Nanobody. Cell 176 479-490.e12 PMID: 30639100

Pedersen (2021) A novel luminescence-based-β-arrestin recruitment assay for unmodified receptors. J Biol. Chem. 296 100503 PMID: 33684444

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