Ondansetron hydrochloride

Cat. No. 2891 5 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Selective 5-HT₃ antagonist

别名： GR 38032

化学名： 1,2,3,9-Tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one hydrochloride

纯度： ≥99% (HPLC)

引用文献 (5)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Ondansetron hydrochloride

Ondansetron hydrochloride is a selective 5-HT₃ receptor antagonist (K_i= 6.16 nM). Also an inhibitor of human multidrug and toxin extrusion (MATE) transporter 1 (IC₅₀ = <10-160 nM). Ondansetron blocks 5-HT-evoked transient inward currents (IC₅₀= 0.1 nM) in human recombinant h5-HT_3A receptors. In an animal model of Parkinson's disease, Ondansetron reduces both the severity of dyskinesia and psychosis-like behaviors. Antiemetic; prevents emesis induced by cytotoxic drugs and radiation.

技术数据 for Ondansetron hydrochloride

分子量	329.83
公式	C₁₈H₁₉N₃O.HCl
储存	Store at RT
纯度	≥99% (HPLC)
CAS Number	99614-01-4
PubChem ID	68647
InChI Key	MKBLHFILKIKSQM-UHFFFAOYSA-N
Smiles	CN1C3=C(C=CC=C3)C2=C1CCC(CN4C(C)=NC=C4)C2=O.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Ondansetron hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	16.49	50
	DMSO	32.98	100

制备储备液 for Ondansetron hydrochloride

以下数据基于产品分子量 329.83。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.03 mL	15.16 mL	30.32 mL
5 mM	0.61 mL	3.03 mL	6.06 mL
10 mM	0.3 mL	1.52 mL	3.03 mL
50 mM	0.06 mL	0.3 mL	0.61 mL

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产品说明书 for Ondansetron hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Ondansetron hydrochloride

参考文献是支持产品生物活性的出版物。

Youssefyeh et al (1992) Development of high-affinity 5-HT₃ receptor antagonists. 1. Initial structure-activity relationship of novel benzamides. J.Med.Chem. 35 895 PMID: 1312602

Ye et al (2001) Ondansetron: a selective 5-HT₃ receptor antagonist and its applications in CNS-related disorders. CNS Drug Rev. 7 199 PMID: 11474424

Ginawi et al (2005) Ondansetron, a selective antagonist, antagonizes methamphetamine-induced anorexia in mice. Pharmacol.Res. 51 255 PMID: 15661576

Wittwer et al (2013) Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling. J.Med.Chem. 56 781 PMID: 23241029

Brown et al (1998) Ion permeation and conduction in a human recombinant 5-HT3 receptor subunit (h5-HT3A). J.Physiol. 507 653 PMID: 9508827

Kwan et al (2021) Selective blockade of the 5-HT₃ receptor acutely alleviates dyskinesia and psychosis in the parkinsonian marmoset. Neuropharmacology 182 PMID: 33152452

If you know of a relevant reference for Ondansetron hydrochloride, please let us know.

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关键词: Ondansetron hydrochloride, Ondansetron hydrochloride supplier, Selective, 5-HT3, antagonists, Serotonin, Receptors, GR38032, antiparkinsons, parkinsons, MATE, transporter, GR, 38032, Multidrug, Transporters, 2891, Tocris Bioscience

5 篇 Ondansetron hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Ondansetron hydrochloride 的部分引用包括：

Jin et al (2014) Ginger and its pungent constituents non-competitively inhibit serotonin currents on visceral afferent neurons. Korean J Physiol Pharmacol 18 149 PMID: 24757377

Pezeshki et al (2016) Low protein diets produce divergent effects on energy balance. PLoS One 6 25145 PMID: 27122299

Amorim et al (2015) Galanin-Mediated Behavioural Hyperalgesia from the Dorsomedial Nucleus of the Hypothalamus Involves Two Independent Descending Pronociceptive Pathways. Antioxid Redox Signal 10 e0142919 PMID: 26565961

Spring et al (2019) Methionine Restriction Partly Recapitulates the Sympathetically Mediated Enhanced Energy Expenditure Induced by Total Amino Acid Restriction in Rats. Nutrients 11 PMID: 30917593

Capasso et al (2012) Modulation of mouse gastrointestinal motility by allyl isothiocyanate, a constituent of cruciferous vegetables (Brassicaceae): evidence for TRPA1-independent effects. Br J Pharmacol 165 1966 PMID: 21955242

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