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ONO 1078

Cat. No. 3026 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3026 has been discontinued.

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说明： Selective CysLT1 antagonist; also TREK2 activator
别名： Pranlukast
化学名： N-[4-Oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4(4-phenylbutoxy)benzamide
纯度： ≥99% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 说明书 参考文献

生物活性 for ONO 1078

ONO 1078 is a selective cysteinyl leukotriene receptor 1 (CysLT1) antagonist (IC50 values are ~ 4 - 7 and 3620 nM for CysLT1 and CysLT2 respectively). Inhibits contraction of airway smooth muscle, microvascular leakage into airways and eosinophil infiltration. Can decrease symptoms of bronchial asthma. Also TREK2 activator (pEC50 = 5.8); exhibits selectivity for TREK-2 over other K2P channels.

技术数据 for ONO 1078

分子量 481.5
公式 C27H23N5O4
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 103177-37-3
PubChem ID 4887
InChI Key NBQKINXMPLXUET-UHFFFAOYSA-N
Smiles O=C2C1=CC=CC(NC(C4=CC=C(OCCCCC5=CC=CC=C5)C=C4)=O)=C1OC(C3=NN=NN3)=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for ONO 1078

参考文献是支持产品生物活性的出版物。

Lynch et al (1999) Characterization of the human leukotriene CysLT1 receptor. Nature 399 789 PMID: 10391245

Heise et al (2000) Characterization of the human cysteinyl leukotriene 2 receptor. J.Biol.Chem. 275 30531 PMID: 10851239

Suzuki et al (2003) Inhibition of human eosinophil activation by a cysteinyl leukotriene receptor antagonist (Pranlukast; ONO-1078). J.Asthma 40 395 PMID: 12870835

Wright et al (2019) Pranlukast is a novel small molecule activator of the two-pore domain potassium channel TREK2. Biochem.Biophys.Res.Commun. 520 35 PMID: 31564414

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关键词: ONO 1078, ONO 1078 supplier, Selective, CysLT1, antagonists, Receptors, leukotrienes, eicosanoids, ONO1078, TREK-2, activators, activates, K2P10.1, Pranlukast, Leukotriene, and, Related, Two-P, Potassium, Channels, 3026, Tocris Bioscience

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