ONO AE3 208

Cat. No. 3565 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： High affinity and selective EP₄ antagonist

化学名： 4-Cyano-2-[[2-(4-fluoro-1-naphthalenyl)-1-oxopropyl]amino]benzenebutanoic acid

纯度： ≥98% (HPLC)

引用文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for ONO AE3 208

ONO AE3 208 is a high affinity and selective EP₄ receptor antagonist (K_i values are 1.3, 30, 790 and 2400 nM for EP₄, EP₃, FP and TP receptors respectively). Displays no affinity for EP₁, EP₂, DP or IP receptors (K_i >10 μM). Inhibits PGE₂-induced IL-8 production in colonic epithelial caco-2 cells and attenuates PGE₂ inhibition of natural killer T cell activation. Suppresses recovery from experimentally-induced colitis and stimulates CD4⁺ T cell proliferation in C57BL/6 mice. Also reduces metastasis of mammary tumor cells in a murine model of breast cancer. Orally active.

技术数据 for ONO AE3 208

分子量	404.43
公式	C₂₄H₂₁FN₂O₃
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	402473-54-5
PubChem ID	10111831
InChI Key	MTDIMKNAJUQTIO-UHFFFAOYSA-N
Smiles	O=C(C(C)C2=C(C=CC=C3)C3=C(F)C=C2)NC1=CC(C#N)=CC=C1CCCC(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ONO AE3 208

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	40.44	100

制备储备液 for ONO AE3 208

以下数据基于产品分子量 404.43。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.47 mL	12.36 mL	24.73 mL
5 mM	0.49 mL	2.47 mL	4.95 mL
10 mM	0.25 mL	1.24 mL	2.47 mL
50 mM	0.05 mL	0.25 mL	0.49 mL

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产品说明书 for ONO AE3 208

分析证书/产品说明书

化学品安全技术说明书

参考文献 for ONO AE3 208

参考文献是支持产品生物活性的出版物。

Ma et al (2006) Prostaglandin E receptor EP₄ antagonism inhibits breast cancer metastasis. Cancer Res. 66 2923 PMID: 16540639

Dey et al (2009) Prostaglandin E₂ couples through EP₄ prostanoid receptors to induce IL-8 production in human colonic epithelial cell lines. Br.J.Pharmacol 3 475 PMID: 19175605

Kabashima et al (2002) The prostaglandin receptor EP₄ suppresses colitis, mucosal damage and CD⁴ cell activation in the gut. J.Clin.Invest. 109 883 PMID: 11927615

Deng et al (2013) Exosome-like nanoparticles from intestinal mucosal cells carry prostaglandin E2 and suppress activation of liver NKT cells. J.Immunol. 190 3579 PMID: 23467936

If you know of a relevant reference for ONO AE3 208, please let us know.

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关键词: ONO AE3 208, ONO AE3 208 supplier, ONOAE3208, selective, EP4, receptors, antagonists, prostanoids, PGE2, prostaglandins, high, affinity, orally, active, Prostanoid, Receptors, 3565, Tocris Bioscience

2 篇 ONO AE3 208 的引用文献

引用文献是使用了 Tocris 产品的出版物。 ONO AE3 208 的部分引用包括：

David M et al (2020) The transition of M-CSF-derived human macrophages to a growth-promoting phenotype. Blood Adv 4 5460-5472 PMID: 33166408

Na-Ryum et al (2023) An airway-to-brain sensory pathway mediates influenza-induced sickness. Nature 615 660-667 PMID: 36890237

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