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说明： COMT inhibitor
化学名： 5-[3-(2,5-Dichloro-4,6-dimethyl-1-oxido-3-pyridinyl)-1,2,4-oxadiazol-5-yl]-3-nitro-1,2-benzenediol
纯度： ≥98% (HPLC)
生物活性 for Opicapone
Opicapone is a reversible catechol O-methyltransferase inhibitor (COMT) inhibitor (IC50 = 224 nM). Decreases the ATP content and mitochondrial membrane potential in cells (IC50 values are 98 μM and 181 μM respectively). When administered with L-DOPA (Cat. No. 3788) it attenuates Parkinson's-like symptoms in an MPTP-induced animal model.
技术数据 for Opicapone
| 分子量 | 413.17 |
| 公式 | C15H10Cl2N4O6 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 923287-50-7 |
| PubChem ID | 135565903 |
| InChI Key | ASOADIZOVZTJSR-UHFFFAOYSA-N |
| Smiles | OC1=CC(C2=NC(C3=C(C(Cl)=C([N+]([O-])=C3Cl)C)C)=NO2)=CC([N+]([O-])=O)=C1O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Opicapone
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 41.32 | 100 |
制备储备液 for Opicapone
以下数据基于产品分子量 413.17。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.42 mL | 12.1 mL | 24.2 mL |
| 5 mM | 0.48 mL | 2.42 mL | 4.84 mL |
| 10 mM | 0.24 mL | 1.21 mL | 2.42 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
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产品说明书 for Opicapone
参考文献 for Opicapone
参考文献是支持产品生物活性的出版物。
Ettcheto et al (2020) The preclinical discovery and development of opicapone for the treatment of Parkinson's disease. Expert Opin.Drug Discov. 15 993 PMID: 32450711
Bonifácio et al (2021) Opicapone enhances the reversal of MPTP-induced Parkinson-like syndrome by levodopa in cynomolgus monkeys. Eur.J.Pharmacol. 892 173742 PMID: 33220276
If you know of a relevant reference for Opicapone, please let us know.
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关键词: Opicapone, Opicapone supplier, comt, inhibitors, catechol-O-methytransferases, mitochondrial, membrane, potential, ATP, LDOPA, levodopa, Parkinsons, Catechol, O-Methyltransferase, 7668, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.