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OR-486

Cat. No. 0483 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： COMT inhibitor
化学名： 3,5-Dinitrocatechol
纯度： ≥99% (HPLC)
说明书
引用文献 (2)
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for OR-486

OR-486 is a potent and selective inhibitor of catechol-O-methyl-transferase.

技术数据 for OR-486

分子量 200.11
公式 C6H4N2O6
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 7659-29-2
PubChem ID 3870203
InChI Key VDCDWNDTNSWDFJ-UHFFFAOYSA-N
Smiles OC1=CC(=CC(=C1O)[N+]([O-])=O)[N+]([O-])=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for OR-486

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
ethanol 20.01 100
DMSO 20.01 100

制备储备液 for OR-486

以下数据基于产品分子量 200.11。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 5 mL 24.99 mL 49.97 mL
5 mM 1 mL 5 mL 9.99 mL
10 mM 0.5 mL 2.5 mL 5 mL
50 mM 0.1 mL 0.5 mL 1 mL

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产品说明书 for OR-486

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for OR-486

参考文献是支持产品生物活性的出版物。

Mannisto and Kaakola (1990) Rationale for selective COMT inhibitors as adjuncts in the drug treatment of Parkinson's disease. Pharmacol.Toxicol. 66 317 PMID: 2196554

Borgulya et al (1989) Catechol-O-methyltransferase-inhibiting pyrocatechol derivatives: synthesis and structure-activity studies. Helv.Chim.Acta 72 952

If you know of a relevant reference for OR-486, please let us know.

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关键词: OR-486, OR-486 supplier, Catechol, O-methyl, transferase, COMT, inhibitors, inhibits, Adrenergic, Related, Compounds, Dopaminergic-Related, O-Methyltransferase, 0483, Tocris Bioscience

2 篇 OR-486 的引用文献

引用文献是使用了 Tocris 产品的出版物。 OR-486 的部分引用包括：

Ciszek et al (2016) Persistent catechol-O-methyltransferase-dependent pain is initiated by peripheral β-andrenergic receptors. Anesthesiology 124 1122 PMID: 26950706

Oróstica et al (2014) OE increases cAMP in the oviductal secretory cells through a nongenomic mechanism. Reproduction 148 285 PMID: 25038866

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Parkinson's Disease Poster

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