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Submit ReviewOrg 12962 hydrochloride
说明： Selective 5-HT2C agonist
化学名： 1-[6-Chloro-5-trifluoromethyl)-2-pyridinyl]-piperazine hydrochloride
纯度： ≥99% (HPLC)
生物活性 for Org 12962 hydrochloride
Selective 5-HT2C receptor agonist (pEC50 values are 7.01, 6.38 and 6.28 for 5-HT2C, 5-HT2A and 5-HT2B respectively). Displays antiaversive effects in a rat model of panic-like anxiety.
技术数据 for Org 12962 hydrochloride
| 分子量 | 302.12 |
| 公式 | C10H11ClF3N3.HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 210821-63-9 |
| PubChem ID | 9796407 |
| InChI Key | FVDILXYXZAAJOS-UHFFFAOYSA-N |
| Smiles | ClC1=NC(N2CCNCC2)=CC=C1C(F)(F)F.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Org 12962 hydrochloride
参考文献 for Org 12962 hydrochloride
参考文献是支持产品生物活性的出版物。
Jenck et al (1998) Antiaversive effects of 5-HT2C receptor agonists and fluox. in a model of panic-like anxiety in rats. Eur.Neuropsychopharmacol. 8 161 PMID: 9716307
Porter et al (1999) Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells. Br.J.Pharmacol. 128 13 PMID: 10498829
Halford et al (2005) Serotonin (5-HT) drugs: effects on appetite expression and use for the treatment of obesity. Curr.Drug Targets 6 201 PMID: 15777190
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关键词: Org 12962 hydrochloride, Org 12962 hydrochloride supplier, 5-HT2C, agonist, Serotonin, Receptors, 5-HT2, Org12962, hydrochloride, 3585, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.