Org 25543 hydrochloride

Cat. No. 4782 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective GlyT2 inhibitor

化学名： N-[[1-(Dimethylamino)cyclopentyl]methyl]-3,5-dimethoxy-4-(phenylmethoxy)benzamide hydrochloride

纯度： ≥99% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Org 25543 hydrochloride

Org 25543 hydrochloride is a potent and selective glycine transporter type 2 (GlyT2) inhibitor (IC₅₀ = 16 nM for hGlyT2). Displays no activity at GlyT1 or 56 other common biological targets (≥ 100 μM), in a glycine uptake assay in CHO cells. Ameliorates mechanical allodynia after partial sciatic nerve ligation injury in mice.

化合物库 for Org 25543 hydrochloride

Org 25543 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Org 25543 hydrochloride

分子量	448.98
公式	C₂₄H₃₂lN₂O₄.HCl
储存	Desiccate at RT
纯度	≥99% (HPLC)
CAS Number	495076-64-7
PubChem ID	10095215
InChI Key	NIPQJILJYQVZJR-UHFFFAOYSA-N
Smiles	O=C(NCC2(N(C)C)CCCC2)C1=CC(OC)=C(OCC3=CC=CC=C3)C(OC)=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Org 25543 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	8.98	20
	DMSO	44.9	100

制备储备液 for Org 25543 hydrochloride

以下数据基于产品分子量 448.98。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.23 mL	11.14 mL	22.27 mL
5 mM	0.45 mL	2.23 mL	4.45 mL
10 mM	0.22 mL	1.11 mL	2.23 mL
50 mM	0.04 mL	0.22 mL	0.45 mL

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产品说明书 for Org 25543 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Org 25543 hydrochloride

参考文献是支持产品生物活性的出版物。

Caulfield et al (2001) The first potent and selective inhibitors of the glycine transporter type 2. J.Med.Chem. 44 2679 PMID: 11495577

Morita et al (2008) Spinal antiallodynia action of glycine transporter inhibitors in neuropathic pain models in mice. J.Pharmacol.Exp.Ther. 326 633 PMID: 18448867

If you know of a relevant reference for Org 25543 hydrochloride, please let us know.

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