Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewOrg 27569
说明： Potent allosteric modulator of CB1 receptors
化学名： 5-Chloro-3-ethyl-N-[2-[4-(1-piperidinyl)phenyl]ethyl-1H-indole-2-carboxamide
纯度： ≥99% (HPLC)
生物活性 for Org 27569
Org 27569 is a potent CB1 receptor allosteric modulator (pEC50 = 8.24). Significantly increases binding of the CB1 agonist [3H]CP 55.940 (pKb = 5.67) and decreases binding of the CB1 inverse agonist [3H]SR 141716A (pKb = 5.95). Inhibits CB1 receptor antagonist efficacy in vitro (pKb = 7.57).
技术数据 for Org 27569
| 分子量 | 409.95 |
| 公式 | C24H28ClN3O |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 868273-06-7 |
| PubChem ID | 44828492 |
| InChI Key | AHFZDNYNXFMRFQ-UHFFFAOYSA-N |
| Smiles | CCC2=C(C(NCCC3=CC=C(N4CCCCC4)C=C3)=O)NC1=CC=C(Cl)C=C12 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Org 27569
参考文献 for Org 27569
参考文献是支持产品生物活性的出版物。
Price et al (2005) Allosteric modulation of the Cannabinoid CB1 receptor. Mol.Pharmacol. 68 1484 PMID: 16113085
Ross (2007) Allosterism and the cannabinoid CB1 receptors: the shape of things to come. Trends Pharmacol.Sci. 28 567 PMID: 18029031
按标靶查看相关产品
按产品操作查看相关产品
关键词: Org 27569, Org 27569 supplier, Potent, allosteric, CB1, modulators, cannabinoids, Receptors, Org27569, cb1r, 2957, Tocris Bioscience
2 篇 Org 27569 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Org 27569 的部分引用包括：
Baillie et al (2013) CB(1) receptor allosteric modulators display both agonist and signaling pathway specificity. Mol Pharmacol 83 322 PMID: 23160940
Cawston et al (2013) Real-time characterization of cannabinoid receptor 1 (CB1 ) allosteric modulators reveals novel mechanism of action. Br J Pharmacol 170 893 PMID: 23937487
Org 27569 的评论
平均评分: 5 (Based on 1 Review.)
Have you used Org 27569?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Filter by:
Works as described, very interesting compound..
By
Jonathan Fay on 05/30/2019
分析类型： In Vitro
种属： Human
细胞系/组织： COSH-1
Allosteric modulation of radioactive Agonist (CP) and Antagonist (SR) binding by various concentrations of Org 27569 and inhibition of agonist stimulated GTPgS binding.
For a constitutively inactive mutant tested, Org 27569 had enhanced potency and appeared to slow radio-labeled agonist dissociation so much that equilibrium was not achieved during the typical 1 hour incubation, at higher Org concentrations.
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Cannabinoid Receptor Ligands Scientific Review
Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.