Oseltamivir phosphate

Cat. No. 7224 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Influenza virus neuraminidase inhibitor; antiviral prodrug

别名： GS 4104

化学名： Ethyl (3R,4R,5S)-4-Acetamido-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylate phosphate

纯度： ≥98% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Oseltamivir phosphate

Oseltamivir phosphate is a viral neuraminidase inhibitor prodrug; metabolized to GS 4071. Metabolite exhibits potent inhibition of neuraminidase from multiple influenza strains (IC₅₀ values range from 0.3 to 2 nM). Inhibits cellular effects of influenza infection in vitro (IC₅₀ values range from 0.6 to 150 nM). Displays highest potency against H1N1 and H3N2 influenza A strains. Inhibits H1N1 influenza infection in mice.

化合物库 for Oseltamivir phosphate

Oseltamivir phosphate is also offered as part of the Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Oseltamivir phosphate

分子量	410.4
公式	C₁₆H₂₈N₂O₄.H₃PO₄
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	204255-11-8
PubChem ID	78000
InChI Key	PGZUMBJQJWIWGJ-ONAKXNSWSA-N
Smiles	O[P](O)(O)=O.CCOC(=O)C1=C[C@@H](OC(CC)CC)[C@H](NC(C)=O)[C@@H](N)C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Oseltamivir phosphate

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	41.04	100
	water	41.04	100

制备储备液 for Oseltamivir phosphate

以下数据基于产品分子量 410.4。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.44 mL	12.18 mL	24.37 mL
5 mM	0.49 mL	2.44 mL	4.87 mL
10 mM	0.24 mL	1.22 mL	2.44 mL
50 mM	0.05 mL	0.24 mL	0.49 mL

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产品说明书 for Oseltamivir phosphate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Oseltamivir phosphate

参考文献是支持产品生物活性的出版物。

Kim et al (1997) Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: design, synthesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity. J.Am.Chem.Soc. 119 681 PMID: 16526129

Mendel et al (1998) Oral administration of a prodrug of the influenza virus neuraminidase inhibitor GS 4071 protects mice and ferrets against influenza infection. Antimicrob.Agents Chemother. 42 640 PMID: 9517945

If you know of a relevant reference for Oseltamivir phosphate, please let us know.

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关键词: Oseltamivir phosphate, Oseltamivir phosphate supplier, GS, 4104, viral, neuraminidase, inhibits, inhibitors, influenze, A, b, H2N3, H1H1, antiviral, prodrug, 4071, GS4701, GS4104, Other, Hydrolases, Influenza, Viruses, 7224, Tocris Bioscience

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