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Submit ReviewOXF BD 02
说明： Selective BRD4(1) inhibitor
化学名： 3-(3,5-Dimethyl-4-isoxazolyl)-5-hydroxy-α-phenylbenzenemethanol
纯度： ≥98% (HPLC)
生物活性 for OXF BD 02
OXF BD 02 is a selective inhibitor of the first bromodomain of BRD4 (BRD4(1)) (IC50 = 382 nM). Exhibits 2-3-fold selectivity for BRD4(1) over the CBP bromodomain and has little affinity for a range of other bromodomains. Reduces viability of lung adenocarcinoma cell lines and attenuates proliferation of MV-4-11 leukemia cells. Cell permeable.
许可信息
Sold with the agreement of the University of Oxford
技术数据 for OXF BD 02
| 分子量 | 295.33 |
| 公式 | C18H17NO3 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1429129-68-9 |
| PubChem ID | 56929801 |
| InChI Key | FEQUIPXIENTMJN-UHFFFAOYSA-N |
| Smiles | OC1=CC(C2=C(C)ON=C2C)=CC(C(O)C3=CC=CC=C3)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for OXF BD 02
参考文献 for OXF BD 02
参考文献是支持产品生物活性的出版物。
Hewings et al (2011) 3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands. J.Med.Chem. 54 6761 PMID: 21851057
Hewings et al (2013) Optimization of 3,5-dimethylisoxazole derivatives as potent bromodomain ligands. J.Med.Chem. 56 3217 PMID: 23517011
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关键词: OXF BD 02, OXF BD 02 supplier, OXFBD02, selective, bromodomains, BRD, BRD4(1), inhibitors, cell, permeable, antiproliferative, inhibits, Bromodomains, 4928, Tocris Bioscience
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