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Submit ReviewOxytocin
说明： Involved in uterine contraction and lactation
纯度： ≥95% (HPLC)
生物活性 for Oxytocin
Oxytocin is a neurohypophyseal peptide. Stimulates uterine contraction and lactation.
技术数据 for Oxytocin
| 分子量 | 1007.19 |
| 公式 | C43H66N12O12S2 |
| 序列 |
CYIQNCPLG (Modifications: Gly-9 = C-terminal amide, disulfide bridge: 1-6) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 50-56-6 |
| PubChem ID | 439302 |
| InChI Key | XNOPRXBHLZRZKH-DSZYJQQASA-N |
| Smiles | [H]N[C@H]1CSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CC2=CC=C(O)C=C2)NC1=O)[C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Oxytocin
| 溶解性 | Soluble to 1 mg/ml in water |
产品说明书 for Oxytocin
参考文献 for Oxytocin
参考文献是支持产品生物活性的出版物。
Barberis and Tribolle (1996) Vasopressin and oxyt. receptors in the central nervous system. Crit.Rev.Neurobiol. 10 119 PMID: 8853957
Thibonnier et al (1998) Signal transduction pathways of the human V1-vascular V2-renal, V3-pituitary vasopressin and oxyt. receptors. Prog.Brain Res. 119 147 PMID: 10074787
If you know of a relevant reference for Oxytocin, please let us know.
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关键词: Oxytocin, Oxytocin supplier, Involved, uterine, contraction, lactation, OT, Receptors, agonists, Oxytocin, 1910, Tocris Bioscience
6 篇 Oxytocin 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Oxytocin 的部分引用包括：
Xiao et al (2018) OXT functions as a spatiotemporal filter for excitatory synaptic inputs to VTA DA neurons. Elife 7 PMID: 29676731
Rapanelli et al (2017) Targeted Interneuron Depletion in the Dorsal Striatum Produces Autism-like Behavioral Abnormalities in Male but Not Female Mice. Biol Psychiatry 82 194 PMID: 28347488
Nøhr et al (2017) The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW. Neurochem Int 102 105 PMID: 27916541
Spaethling et al (2014) Serotonergic neuron regulation informed by in vivo single-cell transcriptomics. Hypertension 28 771 PMID: 24192459
Brierley et al (2021) Central and peripheral GLP-1 systems independently and additively suppress eating. Nat Metab 3 258 PMID: 33589843
Ferreira et al (2019) OXT can regulate myometrial smooth muscle excitability by inhibiting the Na+ -activated K+ channel, Slo2.1. J Physiol 597 137 PMID: 30334255
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Oxytocin 的评论
平均评分: 4.7 (基于 3 条评论。)
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Stimulation of gut smooth muscle.
By
Mohammad Alqudah on 10/19/2022
分析类型： Ex Vivo
种属： Rat
细胞系/组织： Smooth muscle
Used to stimulate gut smooth muscle contraction from rats at concentrations of 10-9 to 10-5
Works as expected..
By
Anonymous on 06/01/2020
分析类型： Ex Vivo
种属： Mouse
细胞系/组织： Paraventricular nucleus of hypothalamus
Preincubation of slices in oxytocin (200 nM) resulted in an increase in holding current when compared to slices incubated in normal ACSF.
Applied to smooth muscle in tissue bath.
By
John Broad on 01/05/2018
种属： Rat
Applied to rat uterus and human smooth muscle
Do not freeze thaw