Ozagrel hydrochloride

Name: Ozagrel hydrochloride
Brand: Tocris Bioscience
SKU: 1510

Cat. No. 1510 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1510 has been discontinued.

View all Prostanoid Receptors products.

说明： Selective thromboxane A₂ synthetase inhibitor

别名： OKY 046

化学名： (2E)-3-[4-(1H-Imidazol-1-ylmethyl)phenyl]-2-propenoic acid hydrochloride

纯度： ≥98% (HPLC)

说明书

引用文献 (2)

生物活性技术数据说明书参考文献

生物活性 for Ozagrel hydrochloride

Ozagrel hydrochloride is a potent and selective inhibitor of thromboxane (TXA₂) synthetase (IC₅₀ = 4 nM). Does not inhibit prostacyclin (PGI₂) synthetase, cyclooxygenase or PGE₂ isomerase (IC₅₀ > 1 mM). Inhibits platelet aggregation in vitro and arachidonate-induced arterial contraction in vivo.

技术数据 for Ozagrel hydrochloride

分子量	264.71
公式	C₁₃H₁₂N₂O₂.HCl
储存	Store at RT
纯度	≥98% (HPLC)
CAS Number	78712-43-3
PubChem ID	6438130
InChI Key	CWKFWBJJNNPGAM-IPZCTEOASA-N
Smiles	Cl[H].OC(=O)\C=C\C1=CC=C(CN2C=CN=C2)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Ozagrel hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Ozagrel hydrochloride

参考文献是支持产品生物活性的出版物。

Hiraku et al (1986) Pharmacological studies on the TXA₂ synthetase inhibitor (E)-3-[p-(1H-imidazol-1ylmethyl)phenyl]-2-propenoic acid (OKY-046). Jpn.J.Pharmacol. 41 393 PMID: 3093741

Naito et al (1983) Effects of thromboxane synthetase inhibitors on aggregation of rabbit platelets. Eur.J.Pharmacol. 91 41 PMID: 6413227

Shinagawa et al (2000) Participation of thromboxane A₂ in the cough response in guinea-pigs: antitussive effect of ozagrel. Br.J.Pharmacol. 131 266 PMID: 10991919

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2 篇 Ozagrel hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Ozagrel hydrochloride 的部分引用包括：

Wong et al (2009) Cyclooxygenase-2-derived prostaglandin F2alpha mediates endothelium-dependent contractions in the aortae of hamsters with increased impact during aging. Circ Res 104 228 PMID: 19096033

Rancillac et al (2006) Glutamatergic Control of Microvascular Tone by Distinct GABA Neurons in the Cerebellum. Proc Natl Acad Sci U S A 26 6997 PMID: 16807329