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P-3FAX-Neu5Ac

Cat. No. 5760 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Sialic acid analog; sialyltransferase inhibitor
化学名： 5-(acetylamino)-3,5-dideoxy-3-fluoro-D-erythro-α-L-manno-2-nonulopyranosonic acid methyl ester 2,4,7,8,9-pentaacetate
纯度： ≥97% (HPLC)
说明书
引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for P-3FAX-Neu5Ac

P-3FAX-Neu5Ac is a cell-permeable sialic acid analog. Deacetylation occurs intracellularly giving rise to a sialyltransferase inhibitor. Abolishes expression of SLex expression on HL-60 cells and reduces E-selectin and P-selectin binding. Prevents metastasis formation in a mouse lung metastasis model.

技术数据 for P-3FAX-Neu5Ac

分子量 551.47
公式 C22H30FNO14
储存 Store at -20°C
纯度 ≥97% (HPLC)
CAS Number 117405-58-0
PubChem ID 72698605
InChI Key COXHVKPJIOSDPS-RTEYEINBSA-N
Smiles FC1C(OC(C)=O)C(NC(C)=O)C([C@H](OC(C)=O)[C@H](OC(C)=O)COC(C)=O)OC(C(OC)=O)1OC(C)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for P-3FAX-Neu5Ac

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 55.15 100
ethanol 27.57 50

制备储备液 for P-3FAX-Neu5Ac

以下数据基于产品分子量 551.47。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.81 mL 9.07 mL 18.13 mL
5 mM 0.36 mL 1.81 mL 3.63 mL
10 mM 0.18 mL 0.91 mL 1.81 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

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产品说明书 for P-3FAX-Neu5Ac

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for P-3FAX-Neu5Ac

参考文献是支持产品生物活性的出版物。

Rillahan et al (2012) Global metabolic inhibitors of sialyl- and fucosyltransferases remodel the glycome. Nat.Chem.Biol. 8 661 PMID: 22683610

Büll et al (2015) Targeted delivery of a sialic acid-blocking glycomimetic to cancer cells inhibits metastatic spread. ACS Nano. 9 733 PMID: 25575241

If you know of a relevant reference for P-3FAX-Neu5Ac, please let us know.

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关键词: P-3FAX-Neu5Ac, P-3FAX-Neu5Ac supplier, sialic, acid, analog, sialyltransferases, inhibits, inhibitors, SLeX, Sialyl, Lewis, X, P-selectin, E-selectin, cell, adhesion, metastasis, Other, Transferases, Cell, Adhesion, Molecules, 5760, Tocris Bioscience

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