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Submit ReviewPACMA 31
说明： Irreversible protein disulfide isomerase (PDI) inhibitor
化学名： N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycylglycine ethyl ester
纯度： ≥99% (HPLC)
生物活性 for PACMA 31
PACMA 31 is an irreversible protein disulfide isomerase (PDI) inhibitor; inhibits growth of ovarian cancer cells. Suppresses tumor growth in a mouse xenograph model of human ovarian cancer.
化合物库 for PACMA 31
PACMA 31 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for PACMA 31
| 分子量 | 430.47 |
| 公式 | C21H22N2O6S |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 1401089-31-3 |
| PubChem ID | 66555902 |
| InChI Key | AHOOZADJPNUFOQ-UHFFFAOYSA-N |
| Smiles | O=C(C#C)N(C(C2=CC=CS2)C(NCC(OCC)=O)=O)C1=CC=C(OC)C=C1OC |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for PACMA 31
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 43.05 | 100 |
制备储备液 for PACMA 31
以下数据基于产品分子量 430.47。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.32 mL | 11.62 mL | 23.23 mL |
| 5 mM | 0.46 mL | 2.32 mL | 4.65 mL |
| 10 mM | 0.23 mL | 1.16 mL | 2.32 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
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产品说明书 for PACMA 31
参考文献 for PACMA 31
参考文献是支持产品生物活性的出版物。
Ge et al (2013) Small molecule probe suitable for in situ profiling and inhibition of protein disulfide isomerase. ACS.Chem.Biol. 8 2577 PMID: 24070012
Xu et al (2012) Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment. Proc.Natl.Acad.Sci.U.S.A. 109 16348 PMID: 22988091
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关键词: PACMA 31, PACMA 31 supplier, PACMA31, irreversible, protein, disulfide, isomerases, PDI, inhibitors, inhibits, ovarian, cancer, Protein, Disulfide, Isomerase, 5116, Tocris Bioscience
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