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Submit ReviewPaliperidone
说明： 5-HT2A antagonist; also D2 antagonist; atypical antipsychotic
别名： 9-Hydroxyrisperidone,9-OH-risperidone
化学名： 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
纯度： ≥98% (HPLC)
生物活性 for Paliperidone
Paliperidone is an atypical antipsychotic; metabolite of risperidone (Cat. No. 2865). Exhibits high affinity for 5-HT2A receptors (Ki = 0.4 nM for cloned human 5-HT2A receptors). Also displays nanomolar affinity for human D2 receptors.
技术数据 for Paliperidone
| 分子量 | 426.48 |
| 公式 | C23H27FN4O3 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 144598-75-4 |
| PubChem ID | 115237 |
| InChI Key | PMXMIIMHBWHSKN-UHFFFAOYSA-N |
| Smiles | FC1=CC2=C(C(C3CCN(CCC4=C(C)N=C(C(O)CCC5)N5C4=O)CC3)=NO2)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Paliperidone
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 4.26 | 10 |
制备储备液 for Paliperidone
以下数据基于产品分子量 426.48。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.45 mL | 117.24 mL | 234.48 mL |
| 0.5 mM | 4.69 mL | 23.45 mL | 46.9 mL |
| 1 mM | 2.34 mL | 11.72 mL | 23.45 mL |
| 5 mM | 0.47 mL | 2.34 mL | 4.69 mL |
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产品说明书 for Paliperidone
参考文献 for Paliperidone
参考文献是支持产品生物活性的出版物。
Schotte et al (1996) Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding. Psychopharmacology 124 57 PMID: 8935801
Dremencov et al (2007) Distinct electrophysiological effects of paliper. and risper. on the firing activity of rat serotonin and NE neurons. Psychopharmacology 194 63 PMID: 17530476
Megens and Awouters et al (1994) In vivo pharmacological profile of 9-hydroxyrisperidone, the major metabolite of the novel antipsychotic risper. 33 399
Leysen et al (1994) Risperidone: a novel antipsychotic with balanced serotonin-DA antagonism, receptor occupancy profile, and pharmacologic activity. J.Clin.Psychiatry 55 5 PMID: 7520908
If you know of a relevant reference for Paliperidone, please let us know.
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关键词: Paliperidone, Paliperidone supplier, atypical, antipsychotic, 5-ht2a, serotonergic, serotonin, antagonists, dopamine, dopaminergic, d2, high, affinity, 9-OH-risperidone, 9-hydroxyrisperidone, 9-Hydroxyrisperidone, 5-HT2A, Receptors, D2, 4493, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.