Palmitoylethanolamide

Cat. No. 0879 10 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Selective GPR55 agonist. FAAH and PAA substrate

别名： PEA

化学名： N-(2-Hydroxyethyl)hexadecanamide

引用文献 (10)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Palmitoylethanolamide

Palmitoylethanolamide is an endogenous lipid that acts as a selective GPR55 agonist (EC₅₀ values are 4, 19 800 and > 30 000 nM at GPR55, CB₂ and CB₁ receptors respectively). Substrate for fatty acid amide hydrolase (FAAH) and PEA-preferring acid amidase (PAA) and exhibits antinociceptive and anticonvulsant in vivo. Directly activates PPARα (EC₅₀ = 3 μM) producing robust anti-inflammatory actions.

技术数据 for Palmitoylethanolamide

分子量	299.5
公式	C₁₈H₃₇NO₂
储存	Store at RT
CAS Number	544-31-0
PubChem ID	4671
InChI Key	HXYVTAGFYLMHSO-UHFFFAOYSA-N
Smiles	O=C(CCCCCCCCCCCCCCC)NCCO

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Palmitoylethanolamide

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	5.99	20
	ethanol	7.49	25

制备储备液 for Palmitoylethanolamide

以下数据基于产品分子量 299.5。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.25 mM	13.36 mL	66.78 mL	133.56 mL
1.25 mM	2.67 mL	13.36 mL	26.71 mL
2.5 mM	1.34 mL	6.68 mL	13.36 mL
12.5 mM	0.27 mL	1.34 mL	2.67 mL

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产品说明书 for Palmitoylethanolamide

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Palmitoylethanolamide

参考文献是支持产品生物活性的出版物。

Lambert et al (2001) Anticonvulsant activity of N-palmitoylethanolamide, a putative endocannabinoid, in mice. Epilepsia 42 321 PMID: 11442148

Lambert et al (2002) The palmitoylethanolamide family: a new class of anti-inflammatory agents? Curr.Med.Chem. 9 663 PMID: 11945130

Lo Verme et al (2005) The search for the palmitoylethanolamide receptor. Life Sci. 77 1685 PMID: 15963531

Re et al (2005) Palmitoylethanolamide, endocannabinoids and related cannabimimetic compounds in protection against tissue inflammation and pain: potential use in companion animals. Vet.J. 173 21 PMID: 16324856

Ryberg et al (2007) The orphan receptor GPR55 is a novel cannabinoid receptor. Br.J.Pharmacol. 152 1092 PMID: 17876302

If you know of a relevant reference for Palmitoylethanolamide, please let us know.

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关键词: Palmitoylethanolamide, Palmitoylethanolamide supplier, Endogenous, lipid, PPARα, PPARalpha, agonists, activity, Selective, GPR55, FAAH, PAA, PEA-preferring, acid, amidase, Peroxisome, Proliferator-activating, Receptors, PPAR, Cannabinoid, Anandamide, Fatty, Acid, Amide, Hydrolases, PEA, Hydrolase, (FAAH), Other, Cannabinoids, 0879, Tocris Bioscience

10 篇 Palmitoylethanolamide 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Palmitoylethanolamide 的部分引用包括：

Scuderi et al (2012) Palmitoylethanolamide exerts neuroprotective effects in mixed neuroglial cultures and organotypic hippocampal slices via peroxisome proliferator-activated receptor-α. Br J Pharmacol 9 49 PMID: 22405189

Ho et al (2008) 'Entourage' effects of N-palmitoylethanolamide and N-oleoylethanolamide on vasorelaxation to anandamide occur through TRPV1 receptors. Br J Pharmacol 155 837 PMID: 18695637

Melis et al (2008) Endogenous fatty acid ethanolamides suppress nicotine-induced activation of mesolimbic DA neurons through nuclear receptors. J Neurosci 28 13985 PMID: 19091987

Musella (2017) A novel crosstalk within the endocannabinoid system controls GABA transmission in the striatum. Sci Rep 7 7363 PMID: 28779174

Redlich et al (2014) Palmitoylethanolamide stimulates phagocytosis of Escherichia coli K1 by macrophages and increases the resistance of mice against infections. PLoS One 11 108 PMID: 24927796

Raso et al (2015) Palmitoylethanolamide treatment reduces blood pressure in spontaneously hypertensive rats: involvement of cytochrome p450-derived eicosanoids and renin angiotensin system. Int J Mol Sci 10 e0123602 PMID: 25951330

Lin et al (2015) Palmitoylethanolamide inhibits glutamate release in rat cerebrocortical nerve terminals. J Neuroinflammation 16 5555 PMID: 25768340

Maingret et al (2001) The endocannabinoid anandamide is a direct and selective blocker of the background K(+) channel TASK-1. EMBO J 20 47 PMID: 11226154

Chataigneau et al (1998) Cannabinoid CB1 receptor and endothelium-dependent hyperpolarization in guinea-pig carotid, rat mesenteric and porcine coronary arteries. Proc Natl Acad Sci U S A 123 968 PMID: 9535027

Nieri et al (2006) Modulation of P-glycoprotein activity by cannabinoid molecules in HK-2 renal cells. Br J Pharmacol 148 682 PMID: 16715117

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