Palmitoylisopropylamide

Discontinued Product

1815 has been discontinued.

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说明: Inhibitor of FAAH
别名: PIA
化学名: N-(1-Methylethyl)-hexadecanamide
说明书
引用文献
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文献 (1)

生物活性 for Palmitoylisopropylamide

Palmitoylisopropylamide is an inhibitor of fatty acid amide hydrolase (FAAH); pIC50 = 4.89 for inhibition of [3H]-anandamide metabolism. Displays little binding to CB1 and CB2 receptors (IC50 > 100 μM) and very weakly blocks anandamide uptake (IC50 ~ 100 μM). Inhibits proliferation of C6 glioma cells.

技术数据 for Palmitoylisopropylamide

分子量 297.52
公式 C19H39NO
储存 Store at RT
CAS Number 189939-61-5
PubChem ID 5063962
InChI Key TZYVUGCYYQOTQR-UHFFFAOYSA-N
Smiles CCCCCCCCCCCCCCCC(NC(C)C)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

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产品说明书 for Palmitoylisopropylamide

参考文献 for Palmitoylisopropylamide

参考文献是支持产品生物活性的出版物。

Jonsson et al (2001) Effects of homologues and analogues of palmitoylethanolamide upon the inactivation of the endocannabinoid anandamide. Br.J.Pharmacol. 133 1263 PMID: 11498512

Jonsson et al (2003) AM404 and VDM 11 non-specifically inhibit C6 glioma cell proliferation at concentrations used to block the cellular accumulation of the endocannabinoid anandamide. Arch.Toxicol. 77 201 PMID: 12698235

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关键词: Palmitoylisopropylamide, Palmitoylisopropylamide supplier, inhibitors, inhibits, FAAH, cannabinoids, Receptors, Anandamide, Amidase, Fatty, Acid, Amide, Hydrolases, PIA, Other, Cannabinoids, Hydrolase, (FAAH), 1815, Tocris Bioscience

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Cannabinoid Receptor Ligands Scientific Review

Cannabinoid Receptor Ligands Scientific Review

Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.