Palonosetron hydrochloride

Cat. No. 7038 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Highly potent and high affinity 5-HT₃ antagonist

化学名： (3aS)-2-[(3S)-1-azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one hydrochloride

纯度： ≥98% (HPLC)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Palonosetron hydrochloride

Palonosetron hydrochloride is a highly potent and high affinity 5-HT₃ antagonist (IC₅₀ = 0.24 nM for 5-HT_3A; pK_i = 10.4). Displays a slow dissociation rate. Inhibits 5-HT-induced enhancement of cellular response to substance P (Cat. No. 1156) in vitro. Inhibits cisplatin (Cat. No. 2251)-induced enhancement of substance P response in vivo.

技术数据 for Palonosetron hydrochloride

分子量	332.87
公式	C₁₉H₂₄N₂O.HCl
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	135729-62-3
PubChem ID	6918303
InChI Key	OLDRWYVIKMSFFB-SSPJITILSA-N
Smiles	O=C1N([C@@H]2CN3CCC2CC3)C[C@@]4([H])CCCC5=C4C1=CC=C5.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Palonosetron hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	33.29	100
	DMSO	3.33	10

制备储备液 for Palonosetron hydrochloride

以下数据基于产品分子量 332.87。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3 mL	15.02 mL	30.04 mL
5 mM	0.6 mL	3 mL	6.01 mL
10 mM	0.3 mL	1.5 mL	3 mL
50 mM	0.06 mL	0.3 mL	0.6 mL

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产品说明书 for Palonosetron hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Palonosetron hydrochloride

参考文献是支持产品生物活性的出版物。

Wong et al (1995) The interaction of RS 25259-197, a potent and selective antagonist, with 5-HT₃ receptors, in vitro. Br.J.Pharmacol. 114 851 PMID: 7773546

Rojas et al (2010) The antiemetic 5-HT₃ receptor antagonist Palonosetron inhibits substance P-mediated responses in vitro and in vivo. J.Pharmacol.Exp.Ther. 335 362 PMID: 20724484

Lummis & Thompson (2013) Agonists and antagonists induce different palonosetron dissociation rates in 5-HT_3A and 5-HT_3AB receptors. Neuropharmacology. 73 241 PMID: 23747573

Del Cadia et al (2013) Exploring a potential palonosetron allosteric binding site in the 5-HT(3) receptor. Bioorg.Med.Chem. 21 7523 PMID: 24128813

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