Palonosetron hydrochloride

Name: Palonosetron hydrochloride
Brand: Tocris Bioscience
SKU: 7038

Cat. No. 7038 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

7038 has been discontinued.

View all 5-HT<sub>3</sub> Receptors products.

说明： Highly potent and high affinity 5-HT₃ antagonist

化学名： (3aS)-2-[(3S)-1-azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one hydrochloride

纯度： ≥98% (HPLC)

说明书

引用文献

文献 (1)

生物活性技术数据说明书参考文献

生物活性 for Palonosetron hydrochloride

Palonosetron hydrochloride is a highly potent and high affinity 5-HT₃ antagonist (IC₅₀ = 0.24 nM for 5-HT_3A; pK_i = 10.4). Displays a slow dissociation rate. Inhibits 5-HT-induced enhancement of cellular response to substance P (Cat. No. 1156) in vitro. Inhibits cisplatin (Cat. No. 2251)-induced enhancement of substance P response in vivo.

技术数据 for Palonosetron hydrochloride

分子量	332.87
公式	C₁₉H₂₄N₂O.HCl
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	135729-62-3
PubChem ID	6918303
InChI Key	OLDRWYVIKMSFFB-SSPJITILSA-N
Smiles	O=C1N([C@@H]2CN3CCC2CC3)C[C@@]4([H])CCCC5=C4C1=CC=C5.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Palonosetron hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Palonosetron hydrochloride

参考文献是支持产品生物活性的出版物。

Wong et al (1995) The interaction of RS 25259-197, a potent and selective antagonist, with 5-HT₃ receptors, in vitro. Br.J.Pharmacol. 114 851 PMID: 7773546

Rojas et al (2010) The antiemetic 5-HT₃ receptor antagonist Palonosetron inhibits substance P-mediated responses in vitro and in vivo. J.Pharmacol.Exp.Ther. 335 362 PMID: 20724484

Lummis & Thompson (2013) Agonists and antagonists induce different palonosetron dissociation rates in 5-HT_3A and 5-HT_3AB receptors. Neuropharmacology. 73 241 PMID: 23747573

Del Cadia et al (2013) Exploring a potential palonosetron allosteric binding site in the 5-HT(3) receptor. Bioorg.Med.Chem. 21 7523 PMID: 24128813

按标靶查看相关产品

5-HT₃ Receptors

按产品操作查看相关产品

查看全部 5-HT₃ Receptor Antagonists

关键词: Palonosetron hydrochloride, Palonosetron hydrochloride supplier, serotonin, 5-HT3, receptor, antagonist, antagonism, highly, potent, high, potency, affinity, antiemtic, chemotherapy, induced, vomiting, nausea, Receptors, 7038, Tocris Bioscience

篇 Palonosetron hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 Palonosetron hydrochloride 的引用文献。