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Submit ReviewPamoic acid disodium salt
说明： GPR35 agonist
化学名： 4,4'-Methylenebis(3-hydroxy-2-naphthalenecarboxylic acid) disodium salt
纯度： ≥99% (HPLC)
生物活性 for Pamoic acid disodium salt
Pamoic acid disodium salt is a GPR35 agonist. Induces GPR35 internalization and activates ERK1/2 (EC50 values are 22 and 65 nM respectively). Mediates recruitment of β-arrestin2 to GPR35. Also exhibits antinociceptive effects in a mouse model of visceral pain.
技术数据 for Pamoic acid disodium salt
| 分子量 | 432.33 |
| 公式 | C23H14Na2O6 |
| 储存 | Desiccate at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 6640-22-8 |
| PubChem ID | 2723841 |
| InChI Key | YGLLICRFEVEWOZ-UHFFFAOYSA-L |
| Smiles | [Na+].[Na+].OC1=C(CC2=C3C=CC=CC3=CC(C([O-])=O)=C2O)C2=CC=CC=C2C=C1C([O-])=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Pamoic acid disodium salt
参考文献 for Pamoic acid disodium salt
参考文献是支持产品生物活性的出版物。
Zhao et al (2010) Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity. Mol.Pharmacol. 78 560 PMID: 20826425
Jenkins et al (2012) Antagonists of GPR35 display high species ortholog selectivity and varying modes of action. J.Pharmacol.Exp.Ther. 343 683 PMID: 22967846
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关键词: Pamoic acid disodium salt, Pamoic acid disodium salt supplier, gpr35, orphan, gpcr, agonists, GPR35, 4298, Tocris Bioscience
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