PARPYnD

Cat. No. 7410 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： PARP inhibitor; photoaffinity probe

化学名： 3-(3-Butyn-1-yl)-N-[5-cyano-6-[4-[3-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]benzoyl]-1-piperazinyl]-3-pyridinyl]-3H-diazirine-3-propanamide

纯度： ≥95% (HPLC)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for PARPYnD

PARPYnD is a potent photoaffinity probe (AfBP) for poly(ADP-ribose) polymerase (PARP) (IC₅₀ values for PARP2, PARP1 and PARP6 are 6, 38 and 230 nM, respectively). Can be used to fluorescently label PARP1 and PARP2 in cells when an azide functionalized probe is attached via copper catalysed click-chemistry. PARPYnD enriches recombinant PARP6 spiked into cellular lysates and inhibits PARP6 in cell-free assays; does not label PARP6 in intact cells. Photocrosslinking can be performed by irradiating at 365 nm.

技术数据 for PARPYnD

分子量	613.68
公式	C₃₄H₃₁N₉O₃
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	2561483-27-8
InChI Key	ZYWZRMXOMDKHKX-UHFFFAOYSA-N
Smiles	O=C(NC1=CN=C(C(C#N)=C1)N2CCN(C(C3=CC(CC4=NNC(C5=CC=CC=C45)=O)=CC=C3)=O)CC2)CCC6(N=N6)CCC#C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PARPYnD

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	61.37	100

制备储备液 for PARPYnD

以下数据基于产品分子量 613.68。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.63 mL	8.15 mL	16.3 mL
5 mM	0.33 mL	1.63 mL	3.26 mL
10 mM	0.16 mL	0.81 mL	1.63 mL
50 mM	0.03 mL	0.16 mL	0.33 mL

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产品说明书 for PARPYnD

分析证书/产品说明书

化学品安全技术说明书

参考文献 for PARPYnD

参考文献是支持产品生物活性的出版物。

Howard et al (2020) Structure-guided design and in-cell target profiling of a cell-active target engagement probe for PARP inhibitors. ACS Chem.Biol. 15 325 PMID: 32017532

If you know of a relevant reference for PARPYnD, please let us know.

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关键词: PARPYnD, PARPYnD supplier, potent, PARP1, PARP2, PARP6, enzymes, inhibitors, photoaffinity, probes, polymerase, afbp, fluorescent, label, crosslinking, Poly(ADP-ribose), Polymerase, 7410, Tocris Bioscience

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