PBP 10

Name: PBP 10
Brand: Tocris Bioscience
SKU: 4611

Cat. No. 4611 4 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4611 has been discontinued.

View all Formyl Peptide Receptors products.

说明： Selective FPR2 antagonist; cell permeable

纯度： ≥95% (HPLC)

说明书

引用文献 (4)

生物活性技术数据说明书参考文献

生物活性 for PBP 10

PBP 10 is a selective formyl peptide receptor 2 (FPR2) antagonist; cell permeable. Selectively inhibits FPR2-mediated NADPH oxidase activity but has no effect on FPR1 signaling in neutrophils. Displays PIP₂ binding activity in vitro and blocks cell motility. Also exhibits antiviral activity against influenza viruses via inhibition of viral-induced ERK activation.

技术数据 for PBP 10

分子量	1712.1
公式	C₈₄H₁₂₆N₂₄O₁₅
序列	QRLFQVKGRR (Modifications: Gln-1 = Rhodamine-B-Gln)
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	794466-43-6
PubChem ID	16143872
InChI Key	OIOWMSSANHIUTR-NVWDZAHRSA-N
Smiles	CCN(CC)C1=CC2=C(C=C1)C(C1=CC=CC=C1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC([NH-])=N)C(O)=O)=C1C=CC(C=C1O2)=[N+](CC)CC

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for PBP 10

分析证书/产品说明书

化学品安全技术说明书

参考文献 for PBP 10

参考文献是支持产品生物活性的出版物。

Cunningham et al (2011) Cell permeant polyphosphoinositide-binding peptides that block cell motility and actin assembly. J.Biol.Chem. 276 43390 PMID: 11533030

Forsman et al (2012) Structural characterization and inhibitory profile of formyl peptide receptor 2 selective peptides descending from a PIP2-binding domain of gelsolin. J.Immunol. 189 629 PMID: 22706076

Courtin et al (2017) Antiviral activity of formyl peptide receptor 2 antagonists against influenza viruses. Antiviral.Res. 5 252 PMID: 28483551

按标靶查看相关产品

关键词: PBP 10, PBP 10 supplier, PBP10, Polyphosphoinositide-Binding, Peptides, FPR1, FPR2, formyl, receptors, FPRL1, inhibitors, inhibits, antagonists, cell, permeable, antiviral, influenza, ERK, Formyl, Peptide, Receptors, Influenza, Viruses, 4611, Tocris Bioscience