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PCA 4248

Cat. No. 0571 4 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

0571 has been discontinued.

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说明： PAF receptor antagonist
化学名： 1,4-Dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylic acid methyl 2-(phenylthio)ethyl ester
纯度： ≥95%
说明书
引用文献 (4)
评论
生物活性 技术数据 说明书 参考文献

生物活性 for PCA 4248

PCA 4248 is a specific PAF antagonist, more potent than the ginkolide BN-52021. Inhibits rabbit platelet aggregation with an IC50 value of 1.05 μM and has no significant activity on Ca2+ channels. Active in vivo, antagonizing PAF-induced systemic hypotension and protein-plasma extravasation in rats.

技术数据 for PCA 4248

分子量 361.46
公式 C19H23NO4S
储存 Desiccate at -20°C
纯度 ≥95%
CAS Number 123875-01-4
PubChem ID 4698
InChI Key DHCNAWNKZMNTIS-UHFFFAOYSA-N
Smiles COC(=O)C1=C(C)NC(C)=C(C1C)C(=O)OCCSC1=CC=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for PCA 4248

参考文献是支持产品生物活性的出版物。

Fernandez-Gallardo et al (1990) Pharmacological actions of PCA 4248, a new platelet-activating factor receptor antagonist: in vivo studies. J.Pharmacol.Exp.Ther. 255 34 PMID: 2170626

Sunkel et al (1990) 4-Alkyl-1,4-dihydropyridine derivatives as specific PAF-acether antagonists. J.Med.Chem. 33 3205 PMID: 2175357

Sunkel et al (1990) 1,4-Dihydropyridines, a new class of platelet activating factor receptor antagonists: in vitro pharmacological studies. J.Pharmacol.Exp.Ther. 255 28 PMID: 2170624

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关键词: PCA 4248, PCA 4248 supplier, PAF, receptor, antagonists, Receptors, Platelet-activating, Factor, PCA4248, (PAF), 0571, Tocris Bioscience

4 篇 PCA 4248 的引用文献

引用文献是使用了 Tocris 产品的出版物。 PCA 4248 的部分引用包括：

Hergott et al (2015) Bacterial exploitation of phosphorylcholine mimicry suppresses inflammation to promote airway infection. Mediators Inflamm 125 3878 PMID: 26426079

Mathison et al (2004) Effects of cannabinoid receptor-2 activation on accelerated gastrointestinal transit in lipopolysaccharide-treated rats. Br J Pharmacol 142 1247 PMID: 15249429

Garcia et al (2010) Platelet-activating factor receptor plays a role in lung injury and death caused by Influenza A in mice. PLoS Pathog 6 e1001171 PMID: 21079759

Bachi et al (2012) Apoptotic cells contribute to melanoma progression and this effect is partially mediated by the platelet-activating factor receptor. J Pharmacol Exp Ther 2012 610371 PMID: 22577252

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