Platelet-Activating Factor (PAF) Receptors
Platelet-activating factor receptor (PAF-R) is a Gq/G11-coupled-protein receptor that has a role in a wide range of biological processes such as vasodilation, superoxide formation, cell proliferation, angiogenesis and regulation of the inflammatory response.
Platelet-Activating Factor (PAF) Receptor Agonists |
|
|---|---|
| Cat. No. | 产品名称/活性 |
| 7462 | ET 18-OCH3 |
| PAF receptor agonist; selective PI-PLC inhibitor | |
| 2940 | PAF (C16) |
| Endogenous platelet-activating factor (PAF) | |
Platelet-Activating Factor (PAF) Receptor Antagonists |
|
| Cat. No. | 产品名称/活性 |
| 2339 | WEB 2086 |
| Potent PAF receptor antagonist | |
Platelet-activating factor receptor (PAF-R) is a Gq/G11-coupled-protein receptor that has a role in a wide range of biological processes such as vasodilation, superoxide formation, cell proliferation, angiogenesis and regulation of the inflammatory response. PAF-R is linked to multiple intracellular signaling pathways, including the p38 MAPK and PI 3-K pathways, through increasing intracellular calcium mobilization, increasing IP3 synthesis and decreasing cAMP formation.
PAF-R has a wide biological distribution with high expression levels in the spleen and skeletal muscles and lower concentrations in the small intestine, lung, heart and liver. The human gene encoding the PAF-R is located on chromosome 1p35-34.3