主页 / 药理学 / GPCRs / 7-TM Receptors / Acetylcholine Muscarinic Receptors / M4 Receptors / M4 Receptor Antagonists / PD 102807

PD 102807

Cat. No. 1671 4 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Selective M4 antagonist
化学名： 3,6a,11,14-Tetrahydro-9-methoxy-2-methyl-(12H)-isoquino[1,2-b]pyrrolo[3,2-f][1,3]benzoxazine-1-carboxylic acid, ethyl ester
纯度： ≥98% (HPLC)
说明书
引用文献 (4)
评论 (1)
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for PD 102807

PD 102807 is a selective M4 muscarinic receptor antagonist. IC50 values are 91, 6559, 3441, 950 and 7412 nM for human M4, M1, M2, M3, and M5 receptors respectively. Promotes self-renewal of erythroid progenitors.

化合物库 for PD 102807

PD 102807 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for PD 102807

分子量 392.45
公式 C23H24N2O4
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 23062-91-1
PubChem ID 4995951
InChI Key VDDUJINYXKGZLV-UHFFFAOYSA-N
Smiles CCOC(=O)C1=C(C)NC2=CC=C3OC4N(CCC5=CC(OC)=CC=C45)CC3=C12

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PD 102807

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 39.24 100

制备储备液 for PD 102807

以下数据基于产品分子量 392.45。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.55 mL 12.74 mL 25.48 mL
5 mM 0.51 mL 2.55 mL 5.1 mL
10 mM 0.25 mL 1.27 mL 2.55 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

产品说明书 for PD 102807

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for PD 102807

参考文献是支持产品生物活性的出版物。

Augelli-Szafran et al (1998) Identification and characterization of m4 selective muscarinic antagonists. Bioorg.Med.Chem.Lett. 8 1991 PMID: 9873472

Bohme et al (2002) Synthesis and pharmacology of benzoxazines as highly selective antagonists at M4 muscarinic receptors. J.Med.Chem. 45 3094 PMID: 12086495

Kitaichi et al (1999) A novel muscarinic M4 receptor antagonist provides further evidence of an autoreceptor role for the muscarinic M2 receptor sub-type. Eur.J.Pharmacol. 383 53 PMID: 10556681

Trivedi et al (2019) Muscarinic acetylcholine receptor regulates self-renewal of early erythroid progenitors. Sci.Transl.Med. 11 PMID: 31554738

If you know of a relevant reference for PD 102807, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 M4 Receptor Antagonists

关键词: PD 102807, PD 102807 supplier, Selective, M4, antagonists, antagonism, Muscarinic, Receptors, Acetylcholine, ACh, PD102807, expansion, self-renewal, hematopoietic, progenitors, burst-forming, units, erythroid, BFU-E, mAChR4, Stem, Cell, Proliferation, 1671, Tocris Bioscience

4 篇 PD 102807 的引用文献

引用文献是使用了 Tocris 产品的出版物。 PD 102807 的部分引用包括：

Zhu et al (2017) Impairments of spatial memory in an Alzheimer's disease model via degeneration of hippocampal cholinergic synapses. Nat Commun 8 1676 PMID: 29162816

Thomson et al (2017) Cell-Type-Specific Translation Profiling Reveals a Novel Strategy for Treating Fragile X Syndrome. Neuron 95 550 PMID: 28772121

Trivedi et al (2019) Muscarinic acetylcholine receptor regulates self-renewal of early erythroid progenitors. Sci.Transl.Med. 11 PMID: 31554738

Solanki et al (2007) Cholinergic innervation of the guinea-pig isolated vas deferens. Naunyn Schmiedebergs Arch Pharmacol 376 265 PMID: 17992517

您是否知道使用了 Tocris PD 102807 的优秀论文？ 请告知我们.

PD 102807 的评论

平均评分: 5 (Based on 1 Review.)

5 星
100%
4 星
0%
3 星
0%
2 星
0%
1 星
0%

Have you used PD 102807?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


Excellent product.
By Gaurang Trivedi on 06/21/2019
分析类型： In Vitro
种属： Mouse

Used it to test on mice as well as stem cells

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Alzheimer's Disease Poster

Alzheimer's Disease Poster

Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.