PD 144418 oxalate

Name: PD 144418 oxalate
Brand: Tocris Bioscience
SKU: 2606

Cat. No. 2606 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2606 has been discontinued.

说明： High affinity, selective σ₁ ligand

化学名： 1,2,3,6-Tetrahydro-5-[3-(4-methylphenyl)-5-isoxazolyl]-1-propylpyridine oxalate

纯度： ≥98% (HPLC)

说明书

引用文献 (2)

生物活性技术数据说明书参考文献

生物活性 for PD 144418 oxalate

PD 144418 oxalate is a high affinity, selective σ₁ ligand (K_i values are 0.08 and 1377 nM for σ₁ and σ₂ respectively). Displays no significant activity at a wide range of other receptors, ion channels and enzymes. Antagonizes mescaline-induced scratching in mice following i.p. administration. Also attenuates cocaine-induced hyperactivity in mice.

许可信息

Sold for research purposes under agreement from Pfizer Inc.

化合物库 for PD 144418 oxalate

PD 144418 oxalate is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for PD 144418 oxalate

分子量	372.42
公式	C₁₈H₂₂N₂O.C₂H₂O₄
储存	Desiccate at RT
纯度	≥98% (HPLC)
CAS Number	1794760-28-3
PubChem ID	9817231
InChI Key	FOQRKFCLRMMKAT-UHFFFAOYSA-N
Smiles	O=C(O)C(O)=O.CCCN1CC(C2=CC(C3=CC=C(C)C=C3)=NO2)=CCC1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for PD 144418 oxalate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for PD 144418 oxalate

参考文献是支持产品生物活性的出版物。

Akunne et al (1997) The pharmacology of the novel and selective sigma ligand, PD 144418. Neuropharmacology 36 51 PMID: 9144641

Lever et al (2014) Relationship between cerebral sigma-1 receptor occupancy and attenuation of cocaine's motor stimulatory effects in mice by PD144418. J.Pharmacol.Exp.Ther. 351 153 PMID: 25100754

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关键词: PD 144418 oxalate, PD 144418 oxalate supplier, High, affinity, selective, σ1, sigma1, ligands, Receptors, PD144418, oxalate, Pfizer, Sigma1, 2606, Tocris Bioscience

2 篇 PD 144418 oxalate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 PD 144418 oxalate 的部分引用包括：

Navarro et al (2015) Orexin-corticotropin-releasing factor receptor heteromers in the ventral tegmental area as targets for cocaine. Autophagy 35 6639 PMID: 25926444

Sánchez-Blázquez et al (2018) Sigma 1 Receptor Antagonists Inhibit Manic-Like Behaviors in Two Congenital Strains of Mice. Int J Neuropsychopharmacol 21 938 PMID: 29860313