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PD 146176

Cat. No. 2850 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective 15-lipoxygenase inhibitor
化学名： 6,11-Dihydro[1]benzothiopyrano[4,3-b]indole
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for PD 146176

PD 146176 is a specific, non-competitve 15-lipoxygenase (15-LOX) inhibitor (Ki = 197nM) that has no demonstrable effect on 5-LOX, 12-LOX, COX-1 or COX-2 (IC50 = 0.54 μM for 15-LOX in rabbit reticulocytes). Lacks non-specific antioxidant properties and prevents atherogenesis via regulation of monocyte-macrophage enrichment in vivo.

化合物库 for PD 146176

PD 146176 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for PD 146176

分子量 237.32
公式 C15H11NS
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 4079-26-9
PubChem ID 297589
InChI Key ZGOOPZVQMLHPFM-UHFFFAOYSA-N
Smiles C12=CC=CC=C1C3=C(C(C=CC=C4)=C4SC3)N2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PD 146176

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 23.73 100
ethanol 11.87 50

制备储备液 for PD 146176

以下数据基于产品分子量 237.32。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 4.21 mL 21.07 mL 42.14 mL
5 mM 0.84 mL 4.21 mL 8.43 mL
10 mM 0.42 mL 2.11 mL 4.21 mL
50 mM 0.08 mL 0.42 mL 0.84 mL

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参考文献 for PD 146176

参考文献是支持产品生物活性的出版物。

Sendobry et al (1997) Attenuation of diet-induced atherosclerosis in rabbits with a highly selective 15-lipoxygenase inhibitor lacking significant antioxidant properties. Br.J.Pharmacol. 120 1199 PMID: 9105693

Bocan et al (1998) A specific 15-lipoxygenase inhibitor limits the progression and monocyte-macrophage enrichment of hypercholesterolemia-induced atherosclerosis in the rabbit. Atherosclerosis 136 203 PMID: 9543090

Sordillo et al (2005) Enhanced 15-HPETE production during oxidant stress induces apoptosis of endothelial cells. Prostaglandins Other Lipid Mediat. 76 19 PMID: 15967159

If you know of a relevant reference for PD 146176, please let us know.

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关键词: PD 146176, PD 146176 supplier, Selective, 15-lipoxygenase, inhibitors, inhibits, Oxygenases, Oxidases, PD146176, 15-LOX, ferroptosis, Lipoxygenase, Ferroptosis, 2850, Tocris Bioscience

1 篇 PD 146176 的引用文献

引用文献是使用了 Tocris 产品的出版物。 PD 146176 的部分引用包括：

Ruparel et al (2012) Plasticity of cytochrome P450 isozyme expression in rat trigeminal ganglia neurons during inflammation. Cancer Res 153 2031 PMID: 22633978

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