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Submit ReviewPD 153035 hydrochloride
说明： EGFR-kinase inhibitor
别名： ZM 252868
化学名： 4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline hydrochloride
生物活性 for PD 153035 hydrochloride
An extremely potent inhibitor of epidermal growth factor (EGF) receptor tyrosine kinase, with an IC50 of 25 pM. Inhibits other purified tyrosine kinases only at micromolar or higher concentrations.
许可信息
Sold with the permission of AstraZeneca UK Ltd.
技术数据 for PD 153035 hydrochloride
| 分子量 | 396.67 |
| 公式 | C16H14BrN3O2.HCl |
| 储存 | Store at RT |
| CAS Number | 183322-45-4 |
| PubChem ID | 11246488 |
| InChI Key | ZJOKWAWPAPMNIM-UHFFFAOYSA-N |
| Smiles | BrC1=CC=CC(NC3=NC=NC2=CC(OC)=C(OC)C=C23)=C1.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for PD 153035 hydrochloride
参考文献 for PD 153035 hydrochloride
参考文献是支持产品生物活性的出版物。
Bos et al (1997) PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptor activation and inhibits growth of cancer cells in a receptor number-dependent manner. Clin.Cancer Res. 3 2099 PMID: 9815602
Bridges et al (1996) Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor. J.Med.Chem. 39 267 PMID: 8568816
Fry et al (1994) A specific inhibitor of the epidermal growth factor receptor tyrosine kinase. Science 265 1093 PMID: 8066447
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5 篇 PD 153035 hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 PD 153035 hydrochloride 的部分引用包括：
Lahey et al (2017) Signaling pathways induced by serine proteases to increase intestinal epithelial barrier function. PLoS One 12 e0180259 PMID: 28671992
Marshall et al (2018) Analysis of the Intrinsic Self-Organising Properties of Mesenchymal Stromal Cells in Three-Dimensional Co-Culture Models with Endothelial Cells. Bioengineering (Basel) 5 PMID: 30373192
Swanson et al (2012) Inhibition of epidermal growth factor receptor tyrosine kinase ameliorates collagen-induced arthritis. J Immunol 188 3513 PMID: 22393153
Taylor et al (2014) Hepatic nonparenchymal cells drive metastatic breast cancer outgrowth and partial epithelial to mesenchymal transition. Breast Cancer Res Treat 144 551 PMID: 24610032
Xu (2007) EGFR activation results in enhanced cyclooxygenase-2 expression through p38 mitogen-activated protein kinase-dependent activation of the Sp1/Sp3 transcription factors in human gliomas. Cancer Res 67 6121 PMID: 17616668
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