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Submit ReviewPD 160170
说明： Selective non-peptide NPY Y1 receptor antagonist
化学名： 6-[[2-(1-Methylethyl)phenyl]]sulfonyl-5-nitro-8-quinolinamine
纯度： ≥98% (HPLC)
生物活性 for PD 160170
Potent, selective non-peptidic neuropeptide Y1 receptor antagonist (Ki = 48 nM); selective over Y2 and Y5 receptors (Ki > 10 μM). Antagonizes NPY-mediated inhibition of cAMP accumulation in SK-N-MC cells (IC50 = 8.2 nM).
技术数据 for PD 160170
| 分子量 | 371.41 |
| 公式 | C18H17N3O4S |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 181468-88-2 |
| PubChem ID | 9820766 |
| InChI Key | YUVNGBZROXQYQH-UHFFFAOYSA-N |
| Smiles | CC(C)C1=CC=CC=C1S(=O)(=O)C1=CC(N)=C2N=CC=CC2=C1[N+]([O-])=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for PD 160170
参考文献 for PD 160170
参考文献是支持产品生物活性的出版物。
Wright et al (1996) 8-Amino-6-(arylsulphonyl)-5-nitroquinolines: novel nonpeptide neuropeptide Y1 receptor antagonists. Bioorg.Med.Chem.Lett. 6 1809
Wielgosz-Collin et al (2002) 8-Amino-5-nitro-6-phenoxyquinolines:potential non-peptidic neuropeptide Y receptor ligands. J.Enz.Inhib.Med.Chem. 17 449
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关键词: PD 160170, PD 160170 supplier, Selective, non-peptide, NPY, Y1, antagonists, Neuropeptide, Y, Receptors, PD160170, neuropeptides, 2200, Tocris Bioscience
2 篇 PD 160170 的引用文献
引用文献是使用了 Tocris 产品的出版物。 PD 160170 的部分引用包括：
Atasoy et al (2012) Deconstruction of a neural circuit for hunger. Physiol Rep 488 172 PMID: 22801496
Zambrano et al (2015) Density of α4β2* nAChR on the surface of neurons is modulated by chronic antagonist exposure. Pharmacol Res Perspect 3 e00111 PMID: 25729578
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.