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Submit ReviewPD 168368
说明： Selective neuromedin B receptor antagonist (NMB-R, BB1)
化学名： (S)-α-Methyl-α-[[[(4-nitrophenyl)amino]carbonyl]amino]-N-[[1-(2-pyridinyl)cyclohexyl]methyl]-1H-indole-3-propanamide
纯度： ≥96% (HPLC)
生物活性 for PD 168368
Potent neuromedin B receptor antagonist (NMB-R, BB1) (IC50 = 40 nM) that displays ~ 40-fold selectivity over the gastrin-releasing peptide receptor (GRP-R, BB2) and > 300-fold selectivity over BRS-R (bb3). Antagonizes neuromedin B-stimulated calcium release and inhibits proliferation of rat glioma cells (IC50 = 2 μM).
技术数据 for PD 168368
| 分子量 | 554.65 |
| 公式 | C31H34N6O4 |
| 储存 | Store at +4°C |
| 纯度 | ≥96% (HPLC) |
| CAS Number | 204066-82-0 |
| Smiles | O=C(NC3=CC=C([N+]([O-])=O)C=C3)N[C@@](C)(CC5=CNC4=CC=CC=C45)C(NCC1(C2=CC=CC=N2)CCCCC1)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for PD 168368
参考文献 for PD 168368
参考文献是支持产品生物活性的出版物。
Ryan et al (1999) Comparative pharmacology of the nonpeptide neuromedin B receptor antagonist PD 168368 J.Pharmacol.Exp.Ther. 290 1202 PMID: 10454496
Moody et al (2000) Nonpeptide neuromedin B receptor antagonists inhibit the proliferation of C6 cells. Eur.J.Pharmacol. 409 133 PMID: 11104826
Moody et al (2003) Nonpeptide gastrin releasing peptide receptor antagonists inhibit the proliferation of lung cancer cells. Eur.J.Pharmacol. 474 21 PMID: 12909192
Schepetkin et al (2011) Gastrin-releasing peptide/neuromedin B receptor antagonists pD176252, PD168368, and related analogs are potent agonists of human formyl-peptide receptors. Mol.Pharmacol. 79 77 PMID: 20943772
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关键词: PD 168368, PD 168368 supplier, Selective, neuromedin, B, receptor, antagonists, NMB-R, BB1, NMB-Preferring, Bombesin, PD168368, Receptors, 2603, Tocris Bioscience
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