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PD 81723

Cat. No. 1363 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Positive allosteric modulator of A1 receptors
化学名： (2-Amino-4,5-dimethyl-3-thienyl)-[3-(trifluoromethyl)phenyl]methanone
纯度： ≥99% (HPLC)
说明书
引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for PD 81723

PD 81723 is an allosteric potentiator at the adenosine A1 receptor; acts via agonist-dependent and -independent mechanisms. Enhances agonist affinity for, and increased t½ of dissociation from, the receptor. Also inhibits basal and forskolin-stimulated adenylyl cyclase (AC) activity in A1 receptors expressed in CHO cells, possibly via direct potentiation of constitutive receptor activity or by direct inhibition of AC. Active in vivo.

技术数据 for PD 81723

分子量 299.31
公式 C14H12F3NOS
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 132861-87-1
PubChem ID 122028
InChI Key KKDKAWKYGCUOGR-UHFFFAOYSA-N
Smiles CC1=C(C)C(C(=O)C2=CC(=CC=C2)C(F)(F)F)=C(N)S1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PD 81723

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
ethanol 29.93 100
DMSO 29.93 100

制备储备液 for PD 81723

以下数据基于产品分子量 299.31。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.34 mL 16.71 mL 33.41 mL
5 mM 0.67 mL 3.34 mL 6.68 mL
10 mM 0.33 mL 1.67 mL 3.34 mL
50 mM 0.07 mL 0.33 mL 0.67 mL

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产品说明书 for PD 81723

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for PD 81723

参考文献是支持产品生物活性的出版物。

Bruns et al (1990) Structure-activity relationships for enhancement of adenosine A1 receptor binding by 2-amino-3-benzoylthiophenes. Mol.Pharmacol. 38 950 PMID: 2250667

Kollias-Baker et al (1997) Agonist-independent effect of an allosteric enhancer of the A1 adenosine receptor in CHO cells stably expressing the recombinant human A1 receptor. J.Pharmacol.Exp.Ther. 281 761 PMID: 9152383

Mizumura et al (1996) PD 81,723, an allosteric enhancer of the A1 adenosine receptor, lowers the threshold for ischemic preconditioning in dogs. Circ.Res. 79 415 PMID: 8781475

Musser et al (1999) Adenosine A1 receptor-dependent and -independent effects of the allosteric enhancer PD 81,723. J.Pharmacol.Exp.Ther. 288 446 PMID: 9918544

If you know of a relevant reference for PD 81723, please let us know.

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关键词: PD 81723, PD 81723 supplier, Allosteric, potentiators, A1, receptors, Receptors, adenosines, PD81723, Adenosine, 1363, Tocris Bioscience

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