Adenosine A1 Receptors
The A1 receptor is a member of the adenosine receptor group of G-protein-coupled receptors that also includes A2A, A2B and A3. A1 receptors display high expression levels in the brain (cortex, cerebellum, hippocampus), dorsal horn of the spinal cord, eye and atria.
Adenosine A1 Receptor Agonists |
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|---|---|
| Cat. No. | Product Name / Activity |
| 1705 | 2-Chloro-N6-cyclopentyladenosine |
| Potent and selective A1 agonist | |
| 1702 | N6-Cyclopentyladenosine |
| Potent and selective A1 agonist | |
| 3576 | (±)-5'-Chloro-5'-deoxy-ENBA |
| Highly selective A1 agonist | |
| 2281 | 2'-MeCCPA |
| Highly selective and potent A1 receptor agonist | |
| 2465 | SDZ WAG 994 |
| Potent and selective A1 agonist | |
Adenosine A1 Receptor Antagonists |
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| Cat. No. | Product Name / Activity |
| 6137 | 8-Cyclopentyl-1,3-dimethylxanthine |
| High affinity adenosine A1 receptor antagonist | |
| 0439 | DPCPX |
| Selective A1 antagonist | |
| 4167 | KW 3902 |
| Selective A1 antagonist | |
Adenosine A1 Receptor Modulators |
|
| Cat. No. | Product Name / Activity |
| 1363 | PD 81723 |
| Positive allosteric modulator of A1 receptors | |
| 6261 | VCP 171 |
| Positive allosteric modulator (PAM) of A1 receptors; also allosteric partial agonist in absence of orthosteric agonist | |
The A1 receptor is a member of the adenosine receptor group of G-protein-coupled receptors that also includes A2A, A2B and A3. A1 receptors display high expression levels in the brain (cortex, cerebellum, hippocampus), dorsal horn of the spinal cord, eye, adrenal gland and atria. Lower expression levels are also found in the liver, kidney, skeletal muscle, adipose tissue, colon, testes, salivary glands and oesophagus. A1 receptors play a role in lipolysis, antinociception and cardio- and neuroprotection. The human A1 receptor gene is localized on chromosome 1 (1q32.1)